Seroatlas · Human Serome Atlas

AP2B1

AP-2 complex subunit beta

Also known as: ADTB2, AP2B1_HUMAN, CLAPB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63010
Gene: AP2B1
Ensembl: ENSG00000006125
Chromosome: 17
Canonical length: 937 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

937 residues, UniProt reviewed canonical sequence.

>P63010|AP2B1
     1  MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT
    61  DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE
   121  YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA
   181  VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI
   241  CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY
   301  VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
   361  YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK
   421  YPNKYESIIA TLCENLDSLD EPDARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV
   481  QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV
   541  VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST
   601  DAGDSPVGTT TATNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM GAVDLLGGGL
   661  DSLVGQSFIP SSVPATFAPS PTPAVVSSGL NDLFELSTGI GMAPGGYVAP KAVWLPAVKA
   721  KGLEISGTFT HRQGHIYMEM NFTNKALQHM TDFAIQFNKN SFGVIPSTPL AIHTPLMPNQ
   781  SIDVSLPLNT LGPVMKMEPL NNLQVAVKNN IDVFYFSCLI PLNVLFVEDG KMERQVFLAT
   841  WKDIPNENEL QFQIKECHLN ADTVSSKLQN NNVYTIAKRN VEGQDMLYQS LKLTNGIWIL
   901  AELRIQPGNP NYTLSLKCRA PEVSQYIYQV YDSILKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AP2B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 119 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 119 nTPM
cerebral cortex: 107 nTPM
testis: 87 nTPM
choroid plexus: 84 nTPM
rectum: 79 nTPM
spinal cord: 75 nTPM

Single-cell type

late spermatids: 1,152 nCPM
late primary spermatocytes: 613 nCPM
early spermatids: 492 nCPM
neutrophils: 483 nCPM
erythrocyte progenitors: 292 nCPM
cone photoreceptor cells: 275 nCPM

Immune cell

T-reg: 21 nTPM
basophil: 20 nTPM
MAIT T-cell: 17 nTPM
eosinophil: 17 nTPM
non-classical monocyte: 17 nTPM
gdT-cell: 16 nTPM

Brain region

white matter: 184 nTPM
hippocampal formation: 180 nTPM
cerebral cortex: 179 nTPM
basal ganglia: 169 nTPM
hypothalamus: 164 nTPM
thalamus: 157 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 5.17
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AP2B1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AP2B1 as an antibody target. Whether an autoantibody or antibody against AP2B1 could matter depends on whether native AP2B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AP2B1 is annotated at the cell surface, where native AP2B1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AP2B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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