Seroatlas · Human Serome Atlas

DUSP16

Dual specificity protein phosphatase 16

Also known as: DUS16_HUMAN, KIAA1700, MKP-7, MKP7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BY84
Gene
DUSP16
Ensembl
ENSG00000111266
Chromosome
12
Canonical length
665 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

665 residues, UniProt reviewed canonical sequence.

>Q9BY84|DUSP16
     1  MAHEMIGTQI VTERLVALLE SGTEKVLLID SRPFVEYNTS HILEAININC SKLMKRRLQQ
    61  DKVLITELIQ HSAKHKVDID CSQKVVVYDQ SSQDVASLSS DCFLTVLLGK LEKSFNSVHL
   121  LAGGFAEFSR CFPGLCEGKS TLVPTCISQP CLPVANIGPT RILPNLYLGC QRDVLNKELM
   181  QQNGIGYVLN ASNTCPKPDF IPESHFLRVP VNDSFCEKIL PWLDKSVDFI EKAKASNGCV
   241  LVHCLAGISR SATIAIAYIM KRMDMSLDEA YRFVKEKRPT ISPNFNFLGQ LLDYEKKIKN
   301  QTGASGPKSK LKLLHLEKPN EPVPAVSEGG QKSETPLSPP CADSATSEAA GQRPVHPASV
   361  PSVPSVQPSL LEDSPLVQAL SGLHLSADRL EDSNKLKRSF SLDIKSVSYS ASMAASLHGF
   421  SSSEDALEYY KPSTTLDGTN KLCQFSPVQE LSEQTPETSP DKEEASIPKK LQTARPSDSQ
   481  SKRLHSVRTS SSGTAQRSLL SPLHRSGSVE DNYHTSFLFG LSTSQQHLTK SAGLGLKGWH
   541  SDILAPQTST PSLTSSWYFA TESSHFYSAS AIYGGSASYS AYSCSQLPTC GDQVYSVRRR
   601  QKPSDRADSR RSWHEESPFE KQFKRRSCQM EFGESIMSEN RSREELGKVG SQSSFSGSME
   661  IIEVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DUSP16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 39 nTPM
  • liver: 31 nTPM
  • prostate: 16 nTPM
  • vagina: 15 nTPM
  • pancreas: 15 nTPM
  • thymus: 14 nTPM

Single-cell type

  • oligodendrocytes: 218 nCPM
  • papillary tip epithelial cells: 143 nCPM
  • choroid plexus epithelial cells: 122 nCPM
  • podocytes: 116 nCPM
  • oligodendrocyte progenitor cells: 98 nCPM
  • microglia: 90 nCPM

Immune cell

  • T-reg: 3.9 nTPM
  • MAIT T-cell: 2.3 nTPM
  • memory CD4 T-cell: 1.6 nTPM
  • neutrophil: 0.8 nTPM
  • memory CD8 T-cell: 0.7 nTPM
  • gdT-cell: 0.5 nTPM

Brain region

  • white matter: 32 nTPM
  • midbrain: 25 nTPM
  • basal ganglia: 25 nTPM
  • cerebellum: 24 nTPM
  • medulla oblongata: 24 nTPM
  • thalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.09
gnomAD missense Z
0.89
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DUSP16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DUSP16 as an antibody target. Whether an autoantibody or antibody against DUSP16 could matter depends on whether native DUSP16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DUSP16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DUSP16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DUSP16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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