Seroatlas · Human Serome Atlas

GPR35

G-protein coupled receptor 35

Also known as: GPR35_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HC97
Gene: GPR35
Ensembl: ENSG00000178623
Chromosome: 2
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Enables C-X-C chemokine receptor activity. Involved in chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q9HC97|GPR35
     1  MNGTYNTCGS SDLTWPPAIK LGFYAYLGVL LVLGLLLNSL ALWVFCCRMQ QWTETRIYMT
    61  NLAVADLCLL CTLPFVLHSL RDTSDTPLCQ LSQGIYLTNR YMSISLVTAI AVDRYVAVRH
   121  PLRARGLRSP RQAAAVCAVL WVLVIGSLVA RWLLGIQEGG FCFRSTRHNF NSMAFPLLGF
   181  YLPLAVVVFC SLKVVTALAQ RPPTDVGQAE ATRKAARMVW ANLLVFVVCF LPLHVGLTVR
   241  LAVGWNACAL LETIRRALYI TSKLSDANCC LDAICYYYMA KEFQEASALA VAPSAKAHKS
   301  QDSLCVTLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

duodenum: 44 nTPM
small intestine: 43 nTPM
colon: 30 nTPM
rectum: 21 nTPM
stomach: 17 nTPM
spleen: 11 nTPM

Single-cell type

enterocytes: 125 nCPM
colonocytes: 89 nCPM
tuft cells: 58 nCPM
foveolar cells: 48 nCPM
goblet cells: 42 nCPM
enteric transient amplifying cells: 41 nCPM

Immune cell

intermediate monocyte: 45 nTPM
eosinophil: 33 nTPM
classical monocyte: 31 nTPM
myeloid DC: 28 nTPM
non-classical monocyte: 12 nTPM
total PBMC: 12 nTPM

Brain region

cerebral cortex: 25 nTPM
hippocampal formation: 25 nTPM
amygdala: 24 nTPM
cerebellum: 23 nTPM
basal ganglia: 23 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
G protein-coupled receptor 35, 7TM

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR35 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR35 as an antibody target. Whether an autoantibody or antibody against GPR35 could matter depends on whether native GPR35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR35 is annotated at the cell surface, where native GPR35 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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