Seroatlas · Human Serome Atlas

CXCR1

C-X-C chemokine receptor type 1

Also known as: CD181, CDw128a, CKR-1, CMKAR1, CXCR1_HUMAN, IL8RA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P25024
Gene
CXCR1
Ensembl
ENSG00000163464
Chromosome
2
Canonical length
350 aa
Protein class
Cancer-related genes, CD markers, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>P25024|CXCR1
     1  MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF LLSLLGNSLV
    61  MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN
   121  FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP
   181  NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA
   241  MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL
   301  NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CXCR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 39 nTPM
  • appendix: 24 nTPM
  • adipose tissue: 12 nTPM
  • tongue: 11 nTPM
  • lung: 9.2 nTPM
  • bone marrow: 8.9 nTPM

Single-cell type

  • neutrophils: 413 nCPM
  • neutrophil progenitors: 29 nCPM
  • nk-cells: 5.5 nCPM
  • erythrocytes: 2.1 nCPM
  • late spermatids: 1.4 nCPM
  • pdcs: 1.4 nCPM

Immune cell

  • neutrophil: 1,478 nTPM
  • basophil: 109 nTPM
  • gdT-cell: 24 nTPM
  • naive CD8 T-cell: 8.7 nTPM
  • total PBMC: 8.3 nTPM
  • memory CD8 T-cell: 6.1 nTPM

Brain region

  • cerebral cortex: 3.3 nTPM
  • pons: 2.1 nTPM
  • thalamus: 0.8 nTPM
  • basal ganglia: 0.7 nTPM
  • choroid plexus: 0.7 nTPM
  • medulla oblongata: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0
gnomAD missense Z
-0.41
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CXCR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CXCR1 as an antibody target. Whether an autoantibody or antibody against CXCR1 could matter depends on whether native CXCR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CXCR1 is annotated at the cell surface, where native CXCR1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CXCR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CXCR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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