Seroatlas · Human Serome Atlas

ARRDC1

Arrestin domain-containing protein 1

Also known as: ARRD1_HUMAN, MGC40555

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5I2
Gene: ARRDC1
Ensembl: ENSG00000197070
Chromosome: 9
Canonical length: 433 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables several functions, including arrestin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including extracellular vesicle biogenesis; negative regulation of Notch signaling pathway; and ubiquitin-dependent protein catabolic process. Located in cytoplasmic vesicle; extracellular vesicle; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

433 residues, UniProt reviewed canonical sequence.

>Q8N5I2|ARRDC1
     1  MGRVQLFEIS LSHGRVVYSP GEPLAGTVRV RLGAPLPFRA IRVTCIGSCG VSNKANDTAW
    61  VVEEGYFNSS LSLADKGSLP AGEHSFPFQF LLPATAPTSF EGPFGKIVHQ VRAAIHTPRF
   121  SKDHKCSLVF YILSPLNLNS IPDIEQPNVA SATKKFSYKL VKTGSVVLTA STDLRGYVVG
   181  QALQLHADVE NQSGKDTSPV VASLLQKVSY KAKRWIHDVR TIAEVEGAGV KAWRRAQWHE
   241  QILVPALPQS ALPGCSLIHI DYYLQVSLKA PEATVTLPVF IGNIAVNHAP VSPRPGLGLP
   301  PGAPPLVVPS APPQEEAEAE AAAGGPHFLD PVFLSTKSHS QRQPLLATLS SVPGAPEPCP
   361  QDGSPASHPL HPPLCISTGA TVPYFAEGSG GPVPTTSTLI LPPEYSSWGY PYEAPPSYEQ
   421  SCGGVEPSLT PES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARRDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

esophagus: 60 nTPM
spleen: 53 nTPM
stomach: 52 nTPM
salivary gland: 51 nTPM
liver: 43 nTPM
prostate: 43 nTPM

Single-cell type

renal collecting duct principal cells: 59 nCPM
papillary tip epithelial cells: 57 nCPM
esophageal apical cells: 51 nCPM
breast lactating cells: 50 nCPM
loop of henle epithelial cells: 35 nCPM
cytotrophoblasts: 31 nCPM

Immune cell

eosinophil: 215 nTPM
intermediate monocyte: 133 nTPM
non-classical monocyte: 123 nTPM
myeloid DC: 122 nTPM
basophil: 110 nTPM
classical monocyte: 99 nTPM

Brain region

choroid plexus: 16 nTPM
hippocampal formation: 12 nTPM
cerebral cortex: 11 nTPM
medulla oblongata: 11 nTPM
pons: 11 nTPM
basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: -0.12
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARRDC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARRDC1 as an antibody target. Whether an autoantibody or antibody against ARRDC1 could matter depends on whether native ARRDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARRDC1 is annotated at the cell surface, where native ARRDC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARRDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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