Seroatlas · Human Serome Atlas

CHRM2

Muscarinic acetylcholine receptor M2

Also known as: ACM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P08172
Gene
CHRM2
Ensembl
ENSG00000181072
Chromosome
7
Canonical length
466 aa
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Nucleoli,Golgi apparatus,Plasma membrane,Primary cilium,Basal body

OverviewNCBI Gene

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

466 residues, UniProt reviewed canonical sequence.

>P08172|CHRM2
     1  MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY
    61  FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD
   121  RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF
   181  FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI
   241  VKPNNNNMPS SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE
   301  ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS GQNGDEKQNI
   361  VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT
   421  VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHRM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 34 nTPM
  • colon: 19 nTPM
  • gallbladder: 10 nTPM
  • smooth muscle: 9 nTPM
  • urinary bladder: 8.1 nTPM
  • stomach: 5.5 nTPM

Single-cell type

  • cardiomyocytes: 546 nCPM
  • brain inhibitory neurons: 218 nCPM
  • other brain neurons: 206 nCPM
  • retinal amacrine cells: 156 nCPM
  • smooth muscle cells: 101 nCPM
  • brain excitatory neurons: 56 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 23 nTPM
  • thalamus: 18 nTPM
  • medulla oblongata: 15 nTPM
  • midbrain: 14 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 8.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CHRM2.

Disease | AllUniProt

Conditions CHRM2 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.18
gnomAD missense Z
1.92
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHRM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHRM2 as an antibody target. Whether an autoantibody or antibody against CHRM2 could matter depends on whether native CHRM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHRM2 is annotated at the cell surface, where native CHRM2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CHRM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CHRM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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