Seroatlas · Human Serome Atlas

GPR61

G-protein coupled receptor 61

Also known as: BALGR, GPR61_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZJ8
Gene: GPR61
Ensembl: ENSG00000156097
Chromosome: 1
Canonical length: 451 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>Q9BZJ8|GPR61
     1  MESSPIPQSS GNSSTLGRVP QTPGPSTASG VPEVGLRDVA SESVALFFML LLDLTAVAGN
    61  AAVMAVIAKT PALRKFVFVF HLCLVDLLAA LTLMPLAMLS SSALFDHALF GEVACRLYLF
   121  LSVCFVSLAI LSVSAINVER YYYVVHPMRY EVRMTLGLVA SVLVGVWVKA LAMASVPVLG
   181  RVSWEEGAPS VPPGCSLQWS HSAYCQLFVV VFAVLYFLLP LLLILVVYCS MFRVARVAAM
   241  QHGPLPTWME TPRQRSESLS SRSTMVTSSG APQTTPHRTF GGGKAAVVLL AVGGQFLLCW
   301  LPYFSFHLYV ALSAQPISTG QVESVVTWIG YFCFTSNPFF YGCLNRQIRG ELSKQFVCFF
   361  KPAPEEELRL PSREGSIEEN FLQFLQGTGC PSESWVSRPL PSPKQEPPAV DFRIPGQIAE
   421  ETSEFLEQQL TSDIIMSDSY LRPAASPRLE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GPR61 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 2.3 nTPM

Expression across tissuesHPA

Tissue

retina: 2.3 nTPM
pituitary gland: 1.9 nTPM
cerebral cortex: 0.9 nTPM
choroid plexus: 0.8 nTPM
cerebellum: 0.7 nTPM
thyroid gland: 0.6 nTPM

Single-cell type

retinal pigment epithelial cells: 38 nCPM
corticotrophs: 20 nCPM
retinal bipolar cells: 14 nCPM
lactotrophs: 13 nCPM
adrenal medulla cells: 11 nCPM
other brain neurons: 9.8 nCPM

Immune cell

eosinophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 4.5 nTPM
white matter: 3.9 nTPM
basal ganglia: 3.7 nTPM
cerebellum: 3.4 nTPM
thalamus: 3.2 nTPM
pons: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.78
gnomAD missense Z: 2.09
DepMap mean gene effect: -0.43
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GPR61 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GPR61 as an antibody target. Whether an autoantibody or antibody against GPR61 could matter depends on whether native GPR61 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GPR61 is annotated at the cell surface, where native GPR61 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label GPR61 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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