Seroatlas · Human Serome Atlas

HTR2C

5-hydroxytryptamine receptor 2C

Also known as: 5-HT2C, 5HT2C_HUMAN, 5HTR2C, HTR1C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P28335
Gene
HTR2C
Ensembl
ENSG00000147246
Chromosome
X
Canonical length
458 aa
Protein class
FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

458 residues, UniProt reviewed canonical sequence.

>P28335|HTR2C
     1  MVNLRNAVHS FLVHLIGLLV WQSDISVSPV AAIVTDIFNT SDGGRFKFPD GVQNWPALSI
    61  VIIIIMTIGG NILVIMAVSM EKKLHNATNY FLMSLAIADM LVGLLVMPLS LLAILYDYVW
   121  PLPRYLCPVW ISLDVLFSTA SIMHLCAISL DRYVAIRNPI EHSRFNSRTK AIMKIAIVWA
   181  ISIGVSVPIP VIGLRDEEKV FVNNTTCVLN DPNFVLIGSF VAFFIPLTIM VITYCLTIYV
   241  LRRQALMLLH GHTEEPPGLS LDFLKCCKRN TAEEENSANP NQDQNARRRK KKERRPRGTM
   301  QAINNERKAS KVLGIVFFVF LIMWCPFFIT NILSVLCEKS CNQKLMEKLL NVFVWIGYVC
   361  SGINPLVYTL FNKIYRRAFS NYLRCNYKVE KKPPVRQIPR VAATALSGRE LNVNIYRHTN
   421  EPVIEKASDN EPGIEMQVEN LELPVNPSSV VSERISSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HTR2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
104 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 104 nTPM
  • basal ganglia: 28 nTPM
  • hypothalamus: 13 nTPM
  • amygdala: 2.6 nTPM
  • hippocampal formation: 2.4 nTPM
  • midbrain: 2.2 nTPM

Single-cell type

  • choroid plexus epithelial cells: 18,809 nCPM
  • brain inhibitory neurons: 693 nCPM
  • other brain neurons: 449 nCPM
  • ependymal cells: 314 nCPM
  • pituicytes/fscs: 192 nCPM
  • brain excitatory neurons: 168 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 620 nTPM
  • basal ganglia: 50 nTPM
  • hypothalamus: 40 nTPM
  • hippocampal formation: 30 nTPM
  • medulla oblongata: 29 nTPM
  • midbrain: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HTR2C.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 147 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on HTR2C was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0.04
gnomAD missense Z
1.21
DepMap mean gene effect
0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HTR2C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HTR2C as an antibody target. Whether an autoantibody or antibody against HTR2C could matter depends on whether native HTR2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HTR2C is annotated at the cell surface, where native HTR2C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HTR2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HTR2C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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