GPR84
G-protein coupled receptor 84
Also known as: EX33, GPR84_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NQS5
- Gene
- GPR84
- Ensembl
- ENSG00000139572
- Chromosome
- 12
- Canonical length
- 396 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Part of receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
396 residues, UniProt reviewed canonical sequence.
>Q9NQS5|GPR84
1 MWNSSDANFS CYHESVLGYR YVAVSWGVVV AVTGTVGNVL TLLALAIQPK LRTRFNLLIA
61 NLTLADLLYC TLLQPFSVDT YLHLHWRTGA TFCRVFGLLL FASNSVSILT LCLIALGRYL
121 LIAHPKLFPQ VFSAKGIVLA LVSTWVVGVA SFAPLWPIYI LVPVVCTCSF DRIRGRPYTT
181 ILMGIYFVLG LSSVGIFYCL IHRQVKRAAQ ALDQYKLRQA SIHSNHVART DEAMPGRFQE
241 LDSRLASGGP SEGISSEPVS AATTQTLEGD SSEVGDQINS KRAKQMAEKS PPEASAKAQP
301 IKGARRAPDS SSEFGKVTRM CFAVFLCFAL SYIPFLLLNI LDARVQAPRV VHMLAANLTW
361 LNGCINPVLY AAMNRQFRQA YGSILKRGPR SFHRLHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GPR84 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 22 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 22 nTPM
- urinary bladder: 15 nTPM
- appendix: 7.8 nTPM
- adipose tissue: 4.2 nTPM
- spleen: 3.6 nTPM
- placenta: 2.9 nTPM
Single-cell type
- neutrophils: 71 nCPM
- neutrophil progenitors: 44 nCPM
- monocytes: 36 nCPM
- macrophages: 19 nCPM
- hofbauer cells: 18 nCPM
- cdc: 8.3 nCPM
Immune cell
- myeloid DC: 15 nTPM
- classical monocyte: 9.9 nTPM
- basophil: 9.1 nTPM
- neutrophil: 6 nTPM
- total PBMC: 2.1 nTPM
- intermediate monocyte: 0.4 nTPM
Brain region
- white matter: 4.9 nTPM
- medulla oblongata: 3.9 nTPM
- cerebral cortex: 2.3 nTPM
- thalamus: 2.3 nTPM
- pons: 2.2 nTPM
- hypothalamus: 2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.59
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.4
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GPR84 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GPR84 as an antibody target. Whether an autoantibody or antibody against GPR84 could matter depends on whether native GPR84 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GPR84 is annotated at the cell surface, where native GPR84 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label GPR84 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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