Seroatlas · Human Serome Atlas

ACKR3

Atypical chemokine receptor 3

Also known as: ACKR3_HUMAN, CMKOR1, CXCR7, GPR159, RDC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P25106
Gene
ACKR3
Ensembl
ENSG00000144476
Chromosome
2
Canonical length
362 aa
Protein class
Cancer-related genes, Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>P25106|ACKR3
     1  MDLHLFDYSE PGNFSDISWP CNSSDCIVVD TVMCPNMPNK SVLLYTLSFI YIFIFVIGMI
    61  ANSVVVWVNI QAKTTGYDTH CYILNLAIAD LWVVLTIPVW VVSLVQHNQW PMGELTCKVT
   121  HLIFSINLFG SIFFLTCMSV DRYLSITYFT NTPSSRKKMV RRVVCILVWL LAFCVSLPDT
   181  YYLKTVTSAS NNETYCRSFY PEHSIKEWLI GMELVSVVLG FAVPFSIIAV FYFLLARAIS
   241  ASSDQEKHSS RKIIFSYVVV FLVCWLPYHV AVLLDIFSIL HYIPFTCRLE HALFTALHVT
   301  QCLSLVHCCV NPVLYSFINR NYRYELMKAF IFKYSAKTGL TKLIDASRVS ETEYSALEQS
   361  TK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACKR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
132 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 132 nTPM
  • placenta: 116 nTPM
  • adipose tissue: 115 nTPM
  • urinary bladder: 100 nTPM
  • breast: 73 nTPM
  • heart muscle: 69 nTPM

Single-cell type

  • fibroblasts: 192 nCPM
  • vascular smooth muscle cells: 183 nCPM
  • lymphatic endothelial cells: 174 nCPM
  • fibro-adipogenic progenitors: 150 nCPM
  • schwann cells: 116 nCPM
  • respiratory ionocytes: 74 nCPM

Immune cell

  • NK-cell: 4.7 nTPM
  • MAIT T-cell: 3.8 nTPM
  • memory CD8 T-cell: 3.2 nTPM
  • gdT-cell: 2.5 nTPM
  • T-reg: 2 nTPM
  • naive CD8 T-cell: 1.5 nTPM

Brain region

  • medulla oblongata: 35 nTPM
  • hypothalamus: 28 nTPM
  • choroid plexus: 26 nTPM
  • midbrain: 22 nTPM
  • thalamus: 18 nTPM
  • spinal cord: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACKR3.

Disease | AllUniProt

Conditions ACKR3 is implicated in, by any mechanism.

  • Oculomotor-abducens synkinesis (OCABSN) MIM:619215

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 46 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Oculomotor-abducens synkinesis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.68
gnomAD pLI
0.39
gnomAD missense Z
0.95
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACKR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACKR3 as an antibody target. Whether an autoantibody or antibody against ACKR3 could matter depends on whether native ACKR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACKR3 is annotated at the cell surface, where native ACKR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ACKR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACKR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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