Four-helical cytokine-like, core
IPR009079
Definition
This superfamily contains a domain with a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing this domain include long-chain cytokines, such as leukaemia inhibitory factor (LIF) PMID:14511776, the growth hormone somatotropin PMID:14507421, interleukin-6 PMID:9118960 and leptin PMID:9144295; short-chain cytokines, such as erythropoietin PMID:9783743, stem cell factor (SCF) PMID:10880433, macrophage colony-stimulating factor (M-CSF) and interleukin-2, -3, -4, -5, -13, -15 and -21; and interferons/interleukin-10.
51 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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