Seroatlas · Human Serome Atlas

IFNA21

Interferon alpha-21

Also known as: IFN-alphaI, IFN21_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01568
Gene: IFNA21
Ensembl: ENSG00000137080
Chromosome: 9
Canonical length: 189 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene is a member of the alpha interferon gene cluster on the short arm of chromosome 9. Interferons are cytokines produced in response to viral infection that mediate the immune response and interfere with viral replication. The encoded protein is a type I interferon and may play a specific role in the antiviral response to rubella virus. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>P01568|IFNA21
     1  MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG
    61  FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW EQSLLEKFST ELNQQLNDLE
   121  ACVIQEVGVE ETPLMNVDSI LAVKKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSLSKI
   181  FQERLRRKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFNA21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 0.3 nTPM
hypothalamus: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
midbrain: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

cardiomyocytes: 0.1 nCPM
müller glia: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.5 nTPM
white matter: 1.1 nTPM
pons: 1 nTPM
hypothalamus: 0.8 nTPM
medulla oblongata: 0.8 nTPM
basal ganglia: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -2.14
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFNA21 as an antibody target. Whether an autoantibody or antibody against IFNA21 could matter depends on whether native IFNA21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFNA21 is annotated as secreted, so native IFNA21 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IFNA21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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