IL23A

Protein identityUniProt · HPA

UniProt accession

Q9NPF7

Gene

IL23A

Ensembl

ENSG00000110944

Chromosome

12

Canonical length

189 aa

Protein class

FDA approved drug targets, Predicted secreted proteins

Subcellular location

Cytosol

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>Q9NPF7|IL23A
     1  MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL VGHMDLREEG
    61  DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY EKLLGSDIFT GEPSLLPDSP
   121  VGQLHASLLG LSQLLQPEGH HWETQQIPSL SPSQPWQRLL LRFKILRSLQ AFVAVAARVF
   181  AHGAATLSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL23A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

42 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for IL23A from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.71

gnomAD pLI

0.36

gnomAD missense Z

1.19

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor signaling pathway via JAK-STAT
• cell surface receptor signaling pathway via STAT
• defense response to Gram-negative bacterium
• defense response to virus
• inflammatory response
• innate immune response
• negative regulation of interleukin-10 production
• positive regulation of activated T cell proliferation
• positive regulation of defense response to virus by host
• positive regulation of granulocyte macrophage colony-stimulating factor production
• positive regulation of inflammatory response
• positive regulation of interleukin-10 production
• positive regulation of interleukin-12 production
• positive regulation of interleukin-17 production
• positive regulation of memory T cell differentiation
• positive regulation of natural killer cell activation
• positive regulation of natural killer cell proliferation
• positive regulation of neutrophil chemotaxis
• positive regulation of NK T cell activation
• positive regulation of NK T cell proliferation
• positive regulation of non-canonical NF-kappaB signal transduction
• positive regulation of osteoclast differentiation
• positive regulation of T cell mediated cytotoxicity
• positive regulation of T cell proliferation
• positive regulation of T-helper 1 type immune response
• positive regulation of T-helper 17 cell lineage commitment
• positive regulation of T-helper 17 type immune response
• positive regulation of tissue remodeling
• positive regulation of transcription by RNA polymerase II
• positive regulation of tumor necrosis factor production
• positive regulation of type II interferon production
• T cell proliferation
• tissue remodeling

Molecular functions

• cytokine activity
• interleukin-23 receptor binding

Cellular components

• endoplasmic reticulum lumen
• extracellular region
• interleukin-23 complex

Protein domainsUniProt · Pfam · InterPro

• Four-helical cytokine-like, core
• Interleukin-23 alpha
• Interleukin 23 subunit alpha

KeywordsUniProt

• Antiviral defense
• Cytokine
• Disulfide bond
• Immunity
• Inflammatory response
• Innate immunity
• Secreted
• Signal
• Tissue remodeling

InteractionsUniProt · HPA

Protein binding partners of IL23A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL23R
• IL12B