CSF1

Protein identityUniProt · HPA

UniProt accession

P09603

Gene

CSF1

Ensembl

ENSG00000184371

Chromosome

1

Canonical length

554 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins

Subcellular location

Nuclear bodies,Plasma membrane

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

554 residues, UniProt reviewed canonical sequence.

>P09603|CSF1
     1  MTAPGAAGRC PPTTWLGSLL LLVCLLASRS ITEEVSEYCS HMIGSGHLQS LQRLIDSQME
    61  TSCQITFEFV DQEQLKDPVC YLKKAFLLVQ DIMEDTMRFR DNTPNAIAIV QLQELSLRLK
   121  SCFTKDYEEH DKACVRTFYE TPLQLLEKVK NVFNETKNLL DKDWNIFSKN CNNSFAECSS
   181  QDVVTKPDCN CLYPKAIPSS DPASVSPHQP LAPSMAPVAG LTWEDSEGTE GSSLLPGEQP
   241  LHTVDPGSAK QRPPRSTCQS FEPPETPVVK DSTIGGSPQP RPSVGAFNPG MEDILDSAMG
   301  TNWVPEEASG EASEIPVPQG TELSPSRPGG GSMQTEPARP SNFLSASSPL PASAKGQQPA
   361  DVTGTALPRV GPVRPTGQDW NHTPQKTDHP SALLRDPPEP GSPRISSLRP QGLSNPSTLS
   421  AQPQLSRSHS SGSVLPLGEL EGRRSTRDRR SPAEPEGGPA SEGAARPLPR FNSVPLTDTG
   481  HERQSEGSFS PQLQESVFHL LVPSVILVLL AVGGLLFYRW RRRSHQEPQR ADSPLEQPEG
   541  SPLTQDDRQV ELPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.6

Highest tissue expression

68 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.23

gnomAD pLI

1

gnomAD missense Z

0.51

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• branching involved in mammary gland duct morphogenesis
• cell surface receptor protein tyrosine kinase signaling pathway
• developmental process involved in reproduction
• homeostasis of number of cells within a tissue
• inflammatory response
• innate immune response
• macrophage colony-stimulating factor signaling pathway
• macrophage differentiation
• macrophage homeostasis
• mammary duct terminal end bud growth
• microglial cell proliferation
• monocyte activation
• monocyte differentiation
• monocyte homeostasis
• myeloid leukocyte migration
• neutrophil homeostasis
• osteoclast differentiation
• osteoclast proliferation
• positive regulation of cell migration
• positive regulation of cell population proliferation
• positive regulation of cell-matrix adhesion
• positive regulation of gene expression
• positive regulation of macrophage chemotaxis
• positive regulation of macrophage derived foam cell differentiation
• positive regulation of macrophage differentiation
• positive regulation of macrophage migration
• positive regulation of microglial cell migration
• positive regulation of monocyte differentiation
• positive regulation of mononuclear cell proliferation
• positive regulation of multicellular organism growth
• positive regulation of odontogenesis of dentin-containing tooth
• positive regulation of osteoclast differentiation
• positive regulation of protein metabolic process
• positive regulation of Ras protein signal transduction
• Ras protein signal transduction
• regulation of ossification
• response to ischemia
• mammary gland fat development
• positive regulation of macrophage colony-stimulating factor signaling pathway
• regulation of macrophage derived foam cell differentiation

Molecular functions

• cytokine activity
• growth factor activity
• identical protein binding
• macrophage colony-stimulating factor receptor binding
• protein homodimerization activity

Cellular components

• CSF1-CSF1R complex
• endoplasmic reticulum lumen
• extracellular region
• extracellular space
• membrane
• nuclear body
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Four-helical cytokine-like, core
• Macrophage colony stimulating factor-1
• Macrophage colony stimulating factor-1 (CSF-1)

KeywordsUniProt

• Cell membrane
• Cytokine
• Disulfide bond
• Glycoprotein
• Growth factor
• Immunity
• Inflammatory response
• Innate immunity
• Membrane
• Phosphoprotein
• Proteoglycan
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of CSF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CSF1R