Seroatlas · Human Serome Atlas

IL20

Interleukin-20

Also known as: IL-20, IL10D, IL20_HUMAN, ZCYTO10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYY1
Gene: IL20
Ensembl: ENSG00000162891
Chromosome: 1
Canonical length: 176 aa
Protein class: Predicted secreted proteins
Subcellular location: Endoplasmic reticulum,Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q9NYY1|IL20
     1  MKASSLAFSL LSAAFYLLWT PSTGLKTLNL GSCVIATNLQ EIRNGFSEIR GSVQAKDGNI
    61  DIRILRRTES LQDTKPANRC CLLRHLLRLY LDRVFKNYQT PDHYTLRKIS SLANSFLTIK
   121  KDLRLCHAHM TCHCGEEAMK KYSQILSHFE KLEPQAAVVK ALGELDILLQ WMEETE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 1.6 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 1.6 nTPM
skin: 1.2 nTPM
smooth muscle: 0.6 nTPM
adrenal gland: 0.5 nTPM
seminal vesicle: 0.5 nTPM
breast: 0.3 nTPM

Single-cell type

basal keratinocytes: 51 nCPM
epicardial cells: 48 nCPM
granulosa cells: 22 nCPM
breast hormone-responsive cells: 18 nCPM
salivary basal cells: 16 nCPM
breast secretory cells: 6.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity
interleukin-22 receptor binding
interleukin-20 receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL20 as an antibody target. Whether an autoantibody or antibody against IL20 could matter depends on whether native IL20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL20 is annotated as secreted, so native IL20 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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