CSH1

Protein identityUniProt · HPA

UniProt accession

P0DML2

Gene

CSH1

Ensembl

ENSG00000136488

Chromosome

17

Canonical length

217 aa

Protein class

Predicted intracellular proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

217 residues, UniProt reviewed canonical sequence.

>P0DML2|CSH1
     1  MAPGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFDHAM LQAHRAHQLA IDTYQEFEET
    61  YIPKDQKYSF LHDSQTSFCF SDSIPTPSNM EETQQKSNLE LLRISLLLIE SWLEPVRFLR
   121  SMFANNLVYD TSDSDDYHLL KDLEEGIQTL MGRLEDGSRR TGQILKQTYS KFDTNSHNHD
   181  ALLKNYGLLY CFRKDMDKVE TFLRMVQCRS VEGSCGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

9,234 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.76

gnomAD pLI

0

gnomAD missense Z

-0.59

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• animal organ development
• growth hormone receptor signaling pathway
• positive regulation of receptor signaling pathway via JAK-STAT
• response to nutrient levels

Molecular functions

• growth factor activity
• growth hormone receptor binding
• hormone activity
• metal ion binding

Cellular components

• endoplasmic reticulum
• endosome lumen
• extracellular region
• extracellular space
• vesicle

Protein domainsUniProt · Pfam · InterPro

• Somatotropin/prolactin
• Four-helical cytokine-like, core
• Somatotropin hormone, conserved site
• Somatotropin
• Somatotropin hormone family

KeywordsUniProt

• Disulfide bond
• Hormone
• Metal-binding
• Secreted
• Signal
• Zinc

InteractionsUniProt · HPA

Protein binding partners of CSH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PSMD9