Seroatlas · Human Serome Atlas

IL19

Interleukin-19

Also known as: IL-10C, IL-19, IL19_HUMAN, MDA1, NG.1, ZMDA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHD0
Gene: IL19
Ensembl: ENSG00000142224
Chromosome: 1
Canonical length: 177 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>Q9UHD0|IL19
     1  MKLQCVSLWL LGTILILCSV DNHGLRRCLI STDMHHIEES FQEIKRAIQA KDTFPNVTIL
    61  STLETLQIIK PLDVCCVTKN LLAFYVDRVF KDHQEPNPKI LRKISSIANS FLYMQKTLRQ
   121  CQEQRQCHCR QEATNATRVI HDNYDQLEVH AAAIKSLGEL DVFLAWINKN HEVMFSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

cervix: 19 nTPM
salivary gland: 6.5 nTPM
esophagus: 3.1 nTPM
urinary bladder: 1.3 nTPM
vagina: 1 nTPM
stomach: 0.6 nTPM

Single-cell type

salivary duct cells: 45 nCPM
breast lactating cells: 30 nCPM
endometrial secretory cells: 25 nCPM
endometrial luminal cells: 24 nCPM
monocytes: 19 nCPM
pdcs: 17 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.5 nTPM
thalamus: 1.4 nTPM
cerebellum: 1.1 nTPM
midbrain: 1.1 nTPM
pons: 1.1 nTPM
amygdala: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.67
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL19 as an antibody target. Whether an autoantibody or antibody against IL19 could matter depends on whether native IL19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL19 is annotated as secreted, so native IL19 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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