Seroatlas · Human Serome Atlas

IL13

Interleukin-13

Also known as: ALRH, BHR1, IL-13, IL13_HUMAN, MGC116786, MGC116788, MGC116789, P600

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35225
Gene
IL13
Ensembl
ENSG00000169194
Chromosome
5
Canonical length
146 aa
Protein class
Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>P35225|IL13
     1  MHPLLNPLLL ALGLMALLLT TVIALTCLGG FASPGPVPPS TALRELIEEL VNITQNQKAP
    61  LCNGSMVWSI NLTAGMYCAA LESLINVSGC SAIEKTQRML SGFCPHKVSA GQFSSLHVRD
   121  TKIEVAQFVK DLLLHLKKLF REGQFN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • testis: 23 nTPM
  • gallbladder: 0.5 nTPM
  • appendix: 0.4 nTPM
  • thymus: 0.4 nTPM
  • adipose tissue: 0.2 nTPM
  • bone marrow: 0.2 nTPM

Single-cell type

  • late spermatids: 376 nCPM
  • late primary spermatocytes: 139 nCPM
  • early spermatids: 91 nCPM
  • mast cells: 87 nCPM
  • t-cells: 9.4 nCPM
  • cdc: 2.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • midbrain: 0.1 nTPM
  • pons: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL13.

Disease | AllUniProt

Conditions IL13 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.63
gnomAD pLI
0.01
gnomAD missense Z
0.37
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL13 as an antibody target. Whether an autoantibody or antibody against IL13 could matter depends on whether native IL13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL13 is annotated as secreted, so native IL13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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