IL3

Protein identityUniProt · HPA

UniProt accession

P08700

Gene

IL3

Ensembl

ENSG00000164399

Chromosome

5

Canonical length

152 aa

Protein class

Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>P08700|IL3
     1  MSRLPVLLLL QLLVRPGLQA PMTQTTPLKT SWVNCSNMID EIITHLKQPP LPLLDFNNLN
    61  GEDQDILMEN NLRRPNLEAF NRAVKSLQNA SAIESILKNL LPCLPLATAA PTRHPIHIKD
   121  GDWNEFRRKL TFYLKTLENA QAQQTTLSLA IF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

0.2 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for IL3 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.93

gnomAD pLI

0

gnomAD missense Z

0.23

DepMap mean gene effect

-0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor signaling pathway via STAT
• cell-cell signaling
• embryonic hemopoiesis
• immune response
• interleukin-3-mediated signaling pathway
• nervous system development
• positive regulation of cell population proliferation

Molecular functions

• cytokine activity
• growth factor activity
• interleukin-3 receptor binding

Cellular components

• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Four-helical cytokine-like, core
• Interleukin-3
• Interleukin-3

KeywordsUniProt

• Cytokine
• Disulfide bond
• Glycoprotein
• Growth factor
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL3RA