Seroatlas · Human Serome Atlas

IL11

Interleukin-11

Also known as: AGIF, IL-11, IL11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P20809
Gene: IL11
Ensembl: ENSG00000095752
Chromosome: 19
Canonical length: 199 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>P20809|IL11
     1  MNCVCRLVLV VLSLWPDTAV APGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL
    61  RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK
   121  TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG
   181  LHLTLDWAVR GLLLLKTRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 7.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 7.1 nTPM
pituitary gland: 3.8 nTPM
kidney: 3.7 nTPM
appendix: 3.4 nTPM
hypothalamus: 3.3 nTPM
stomach: 3 nTPM

Single-cell type

fibroblasts: 63 nCPM
melanocytes: 11 nCPM
epididymal basal cells: 8.7 nCPM
pancreatic duct cells: 8.6 nCPM
endometrial luminal cells: 7 nCPM
hepatic stellate cells: 6.5 nCPM

Immune cell

neutrophil: 0.4 nTPM
basophil: 0.3 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

medulla oblongata: 8 nTPM
thalamus: 7.3 nTPM
midbrain: 6.9 nTPM
pons: 6.8 nTPM
hypothalamus: 6.4 nTPM
cerebellum: 5.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: -0.49
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity
growth factor activity
interleukin-11 receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Four-helical cytokine-like, core
Interleukin-11, mammalian
Interleukin-11
Interleukin 11

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL11 as an antibody target. Whether an autoantibody or antibody against IL11 could matter depends on whether native IL11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL11 is annotated as secreted, so native IL11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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