Seroatlas · Human Serome Atlas

CTF1

Cardiotrophin-1

Also known as: CT-1, CT1, CTF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16619
Gene: CTF1
Ensembl: ENSG00000150281
Chromosome: 16
Canonical length: 201 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q16619|CTF1
     1  MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS
    61  FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR
   121  RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL
   181  YREWLSRTEG DLGQLLPGGS A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

ovary: 17 nTPM
endometrium: 16 nTPM
heart muscle: 15 nTPM
blood vessel: 15 nTPM
urinary bladder: 14 nTPM
cervix: 14 nTPM

Single-cell type

smooth muscle cells: 21 nCPM
epididymal basal cells: 21 nCPM
respiratory ciliated cells: 19 nCPM
fallopian tube ciliated cells: 18 nCPM
fallopian secretory cells: 18 nCPM
alveolar cells type 1: 18 nCPM

Immune cell

basophil: 0.6 nTPM
neutrophil: 0.4 nTPM
plasmacytoid DC: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
myeloid DC: 0.2 nTPM
naive B-cell: 0.2 nTPM

Brain region

midbrain: 9.9 nTPM
spinal cord: 9.2 nTPM
medulla oblongata: 8.8 nTPM
choroid plexus: 8.6 nTPM
thalamus: 8 nTPM
white matter: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0.04
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTF1 as an antibody target. Whether an autoantibody or antibody against CTF1 could matter depends on whether native CTF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTF1 is annotated as secreted, so native CTF1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CTF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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