Seroatlas · Human Serome Atlas

IFNK

Interferon kappa

Also known as: IFNK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0W0
Gene: IFNK
Ensembl: ENSG00000147896
Chromosome: 9
Canonical length: 207 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>Q9P0W0|IFNK
     1  MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS MSNSFPVECL
    61  RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ HTFKYWKERH LKQIQIGLDQ
   121  QAEYLNQCLE EDKNENEDMK EMKENEMKPS EARVPQLSSL ELRRYFHRID NFLKEKKYSD
   181  CAWEIVRVEI RRCLYYFYKF TALFRRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFNK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

epicardial cells: 4.5 nCPM
cardiomyocytes: 3.2 nCPM
müller glia: 0.7 nCPM
vascular smooth muscle cells: 0.7 nCPM
macrophages: 0.6 nCPM
neutrophils: 0.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 13 nTPM
medulla oblongata: 12 nTPM
basal ganglia: 11 nTPM
thalamus: 11 nTPM
choroid plexus: 10 nTPM
midbrain: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFNK as an antibody target. Whether an autoantibody or antibody against IFNK could matter depends on whether native IFNK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFNK is annotated as secreted, so native IFNK circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IFNK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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