Seroatlas · Human Serome Atlas

IFNE

Interferon epsilon

Also known as: IFNE_HUMAN, IFNE1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86WN2
Gene: IFNE
Ensembl: ENSG00000184995
Chromosome: 9
Canonical length: 208 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; lymphocyte activation involved in immune response; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q86WN2|IFNE
     1  MIIKHFFGTV LVLLASTTIF SLDLKLIIFQ QRQVNQESLK LLNKLQTLSI QQCLPHRKNF
    61  LLPQKSLSPQ QYQKGHTLAI LHEMLQQIFS LFRANISLDG WEENHTEKFL IQLHQQLEYL
   121  EALMGLEAEK LSGTLGSDNL RLQVKMYFRR IHDYLENQDY STCAWAIVQV EISRCLFFVF
   181  SLTEKLSKQG RPLNDMKQEL TTEFRSPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFNE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 1.4 nTPM

Expression across tissuesHPA

Tissue

esophagus: 1.4 nTPM
urinary bladder: 1.4 nTPM
cerebellum: 1.1 nTPM
cervix: 1.1 nTPM
vagina: 0.9 nTPM
epididymis: 0.8 nTPM

Single-cell type

papillary tip epithelial cells: 2.6 nCPM
renal collecting duct principal cells: 2.1 nCPM
renal collecting duct intercalated cells: 1.2 nCPM
loop of henle epithelial cells: 0.8 nCPM
proximal tubule cells: 0.3 nCPM
renal connecting tubule cells: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 3.1 nTPM
cerebral cortex: 2.1 nTPM
thalamus: 1.5 nTPM
pons: 1.1 nTPM
white matter: 1.1 nTPM
spinal cord: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0.01
gnomAD missense Z: -0.71
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFNE as an antibody target. Whether an autoantibody or antibody against IFNE could matter depends on whether native IFNE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFNE is annotated as secreted, so native IFNE circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IFNE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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