Seroatlas · Human Serome Atlas

IL26

Interleukin-26

Also known as: AK155, IL-26, IL26_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPH9
Gene: IL26
Ensembl: ENSG00000111536
Chromosome: 12
Canonical length: 171 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus,Vesicles
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene was identified by its overexpression specifically in herpesvirus samimiri-transformed T cells. The encoded protein is a member of the IL10 family of cytokines. It is a secreted protein and may function as a homodimer. This protein is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

171 residues, UniProt reviewed canonical sequence.

>Q9NPH9|IL26
     1  MLVNFILRCG LLLVTLSLAI AKHKQSSFTK SCYPRGTLSQ AVDALYIKAA WLKATIPEDR
    61  IKNIRLLKKK TKKQFMKNCQ FQEQLLSFFM EDVFGQLQLQ GCKKIRFVED FHSLRQKLSH
   121  CISCASSARE MKSITRMKRI FYRIGNKGIY KAISELDILL SWIKKLLESS Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

tonsil: 0.9 nTPM
appendix: 0.8 nTPM
urinary bladder: 0.8 nTPM
esophagus: 0.2 nTPM
lymph node: 0.2 nTPM
colon: 0.1 nTPM

Single-cell type

myosatellite cells: 22 nCPM
innate lymphoid cells: 16 nCPM
t-cells: 14 nCPM
plasma cells: 13 nCPM
cardiomyocytes: 8.4 nCPM
b-cells: 4.7 nCPM

Immune cell

MAIT T-cell: 0.4 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

thalamus: 0.4 nTPM
basal ganglia: 0.3 nTPM
amygdala: 0.2 nTPM
cerebral cortex: 0.2 nTPM
midbrain: 0.2 nTPM
white matter: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL26 as an antibody target. Whether an autoantibody or antibody against IL26 could matter depends on whether native IL26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL26 is annotated as secreted, so native IL26 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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