Seroatlas · Human Serome Atlas

OSM

Oncostatin-M

Also known as: MGC20461, ONCM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P13725
Gene
OSM
Ensembl
ENSG00000099985
Chromosome
22
Canonical length
252 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

252 residues, UniProt reviewed canonical sequence.

>P13725|OSM
     1  MGVLLTQRTL LSLVLALLFP SMASMAAIGS CSKEYRVLLG QLQKQTDLMQ DTSRLLDPYI
    61  RIQGLDVPKL REHCRERPGA FPSEETLRGL GRRGFLQTLN ATLGCVLHRL ADLEQRLPKA
   121  QDLERSGLNI EDLEKLQMAR PNILGLRNNI YCMAQLLDNS DTAEPTKAGR GASQPPTPTP
   181  ASDAFQRKLE GCRFLHGYHR FMHSVGRVFS KWGESPNRSR RHSPHQALRK GVRRTRPSRK
   241  GKRLMTRGQL PR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OSM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
112 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 112 nTPM
  • appendix: 14 nTPM
  • urinary bladder: 12 nTPM
  • lung: 7.6 nTPM
  • adipose tissue: 6.8 nTPM
  • gallbladder: 5.8 nTPM

Single-cell type

  • neutrophils: 519 nCPM
  • monocytes: 80 nCPM
  • hofbauer cells: 46 nCPM
  • macrophages: 42 nCPM
  • cdc: 19 nCPM
  • mast cells: 19 nCPM

Immune cell

  • basophil: 66 nTPM
  • neutrophil: 35 nTPM
  • MAIT T-cell: 6.5 nTPM
  • memory CD4 T-cell: 4.8 nTPM
  • NK-cell: 4.3 nTPM
  • memory CD8 T-cell: 2.6 nTPM

Brain region

  • thalamus: 8.3 nTPM
  • cerebral cortex: 5.8 nTPM
  • white matter: 4.9 nTPM
  • choroid plexus: 3.6 nTPM
  • medulla oblongata: 2.9 nTPM
  • pons: 2.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OSM.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 62 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0.59
gnomAD missense Z
0.29
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OSM as an antibody target. Whether an autoantibody or antibody against OSM could matter depends on whether native OSM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OSM is annotated as secreted, so native OSM circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label OSM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/OSM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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