Seroatlas · Human Serome Atlas

FLT3LG

Fms-related tyrosine kinase 3 ligand

Also known as: FLT3L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49771
Gene
FLT3LG
Ensembl
ENSG00000090554
Chromosome
19
Canonical length
235 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted to blood
Quaternary structure
Homodimer

OverviewNCBI Gene

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>P49771|FLT3LG
     1  MTVLAPAWSP TTYLLLLLLL SSGLSGTQDC SFQHSPISSD FAVKIRELSD YLLQDYPVTV
    61  ASNLQDEELC GGLWRLVLAQ RWMERLKTVA GSKMQGLLER VNTEIHFVTK CAFQPPPSCL
   121  RFVQTNISRL LQETSEQLVA LKPWITRQNF SRCLELQCQP DSSTLPPPWS PRPLEATAPT
   181  APQPPLLLLL LLPVGLLLLA AAWCLHWQRT RRRTPRPGEQ VPPVPSPQDL LLVEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FLT3LG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • vagina: 23 nTPM
  • lymph node: 23 nTPM
  • cervix: 23 nTPM
  • thymus: 21 nTPM
  • colon: 20 nTPM
  • adipose tissue: 20 nTPM

Single-cell type

  • decidual stromal cells: 26 nCPM
  • t-cells: 23 nCPM
  • oocytes: 14 nCPM
  • innate lymphoid cells: 10 nCPM
  • leydig cells: 9 nCPM
  • fibroblasts: 8.7 nCPM

Immune cell

  • T-reg: 172 nTPM
  • naive CD4 T-cell: 170 nTPM
  • memory CD4 T-cell: 159 nTPM
  • MAIT T-cell: 145 nTPM
  • naive CD8 T-cell: 138 nTPM
  • memory CD8 T-cell: 102 nTPM

Brain region

  • medulla oblongata: 15 nTPM
  • pons: 13 nTPM
  • white matter: 12 nTPM
  • thalamus: 12 nTPM
  • basal ganglia: 12 nTPM
  • choroid plexus: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FLT3LG.

Disease | AllUniProt

Conditions FLT3LG is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 45 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 125

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.94
gnomAD missense Z
0.9
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FLT3LG as an antibody target. Whether an autoantibody or antibody against FLT3LG could matter depends on whether native FLT3LG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FLT3LG is annotated at the cell surface, where native FLT3LG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FLT3LG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FLT3LG. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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