Seroatlas · Human Serome Atlas

LIF

Leukemia inhibitory factor

Also known as: CDF, DIA, HILDA, LIF_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15018
Gene
LIF
Ensembl
ENSG00000128342
Chromosome
22
Canonical length
202 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Subcellular location
Cytosol
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>P15018|LIF
     1  MKVLAAGVVP LLLVLHWKHG AGSPLPITPV NATCAIRHPC HNNLMNQIRS QLAQLNGSAN
    61  ALFILYYTAQ GEPFPNNLDK LCGPNVTDFP PFHANGTEKA KLVELYRIVV YLGTSLGNIT
   121  RDQKILNPSA LSLHSKLNAT ADILRGLLSN VLCRLCSKYH VGHVDVTYGP DTSGKDVFQK
   181  KKLGCQLLGK YKQIIAVLAQ AF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LIF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
85 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 85 nTPM
  • gallbladder: 45 nTPM
  • adipose tissue: 35 nTPM
  • lung: 32 nTPM
  • appendix: 21 nTPM
  • heart muscle: 18 nTPM

Single-cell type

  • endometrial secretory cells: 370 nCPM
  • endometrial luminal cells: 287 nCPM
  • breast secretory cells: 189 nCPM
  • endometrial glandular cells: 136 nCPM
  • epididymal basal cells: 121 nCPM
  • mast cells: 116 nCPM

Immune cell

  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 11 nTPM
  • thalamus: 4.4 nTPM
  • cerebral cortex: 2.4 nTPM
  • medulla oblongata: 1.5 nTPM
  • midbrain: 1.5 nTPM
  • spinal cord: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0.52
gnomAD missense Z
0.4
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LIF as an antibody target. Whether an autoantibody or antibody against LIF could matter depends on whether native LIF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LIF is annotated as secreted, so native LIF circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label LIF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LIF. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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