Seroatlas · Human Serome Atlas

SLC19A1

Reduced folate transporter

Also known as: FOLT, RFC1, S19A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41440
Gene
SLC19A1
Ensembl
ENSG00000173638
Chromosome
21
Canonical length
591 aa
Protein class
Cancer-related genes, Disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane

OverviewNCBI Gene

The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

591 residues, UniProt reviewed canonical sequence.

>P41440|SLC19A1
     1  MVPSSPAVEK QVPVEPGPDP ELRSWRHLVC YLCFYGFMAQ IRPGESFITP YLLGPDKNFT
    61  REQVTNEITP VLSYSYLAVL VPVFLLTDYL RYTPVLLLQG LSFVSVWLLL LLGHSVAHMQ
   121  LMELFYSVTM AARIAYSSYI FSLVRPARYQ RVAGYSRAAV LLGVFTSSVL GQLLVTVGRV
   181  SFSTLNYISL AFLTFSVVLA LFLKRPKRSL FFNRDDRGRC ETSASELERM NPGPGGKLGH
   241  ALRVACGDSV LARMLRELGD SLRRPQLRLW SLWWVFNSAG YYLVVYYVHI LWNEVDPTTN
   301  SARVYNGAAD AASTLLGAIT SFAAGFVKIR WARWSKLLIA GVTATQAGLV FLLAHTRHPS
   361  SIWLCYAAFV LFRGSYQFLV PIATFQIASS LSKELCALVF GVNTFFATIV KTIITFIVSD
   421  VRGLGLPVRK QFQLYSVYFL ILSIIYFLGA MLDGLRHCQR GHHPRQPPAQ GLRSAAEEKA
   481  AQALSVQDKG LGGLQPAQSP PLSPEDSLGA VGPASLEQRQ SDPYLAQAPA PQAAEFLSPV
   541  TTPSPCTLCS AQASGPEAAD ETCPQLAVHP PGVSKLGLQC LPSDGVQNVN Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC19A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 45 nTPM
  • liver: 21 nTPM
  • duodenum: 21 nTPM
  • basal ganglia: 20 nTPM
  • lung: 16 nTPM
  • cerebral cortex: 15 nTPM

Single-cell type

  • syncytiotrophoblasts: 444 nCPM
  • choroid plexus epithelial cells: 341 nCPM
  • cytotrophoblasts: 208 nCPM
  • neutrophils: 140 nCPM
  • epicardial cells: 109 nCPM
  • retinal pigment epithelial cells: 85 nCPM

Immune cell

  • neutrophil: 103 nTPM
  • eosinophil: 24 nTPM
  • classical monocyte: 19 nTPM
  • intermediate monocyte: 16 nTPM
  • myeloid DC: 13 nTPM
  • non-classical monocyte: 11 nTPM

Brain region

  • choroid plexus: 189 nTPM
  • cerebral cortex: 41 nTPM
  • hippocampal formation: 38 nTPM
  • amygdala: 31 nTPM
  • thalamus: 28 nTPM
  • pons: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC19A1.

Disease | AllUniProt

Conditions SLC19A1 is implicated in, by any mechanism.

  • Megaloblastic anemia, folate-responsive (MEGAF) MIM:601775
  • Immunodeficiency 114, folate-responsive (IMD114) MIM:620603

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 246 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Immunodeficiency 114, folate-responsive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
0.61
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC19A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC19A1 as an antibody target. Whether an autoantibody or antibody against SLC19A1 could matter depends on whether native SLC19A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC19A1 is annotated at the cell surface, where native SLC19A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC19A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC19A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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