Seroatlas · Human Serome Atlas

PTTG1IP

Pituitary tumor-transforming gene 1 protein-interacting protein

Also known as: C21orf1, C21orf3, PBF, PTTG_HUMAN, PTTG1IP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P53801
Gene: PTTG1IP
Ensembl: ENSG00000183255
Chromosome: 21
Canonical length: 180 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

180 residues, UniProt reviewed canonical sequence.

>P53801|PTTG1IP
     1  MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE CLKNVSCLWC
    61  NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII TMSVVGGTLL LGIAICCCCC
   121  CRRKRSRKPD RSEEKAMRER EERRIRQEER RAEMKTRHDE IRKKYGLFKE ENPYARFENN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTTG1IP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 235 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 235 nTPM
placenta: 169 nTPM
stomach: 160 nTPM
lung: 159 nTPM
heart muscle: 156 nTPM
kidney: 155 nTPM

Single-cell type

syncytiotrophoblasts: 471 nCPM
platelets: 437 nCPM
megakaryocytes: 414 nCPM
parietal cells: 359 nCPM
endometrial secretory cells: 356 nCPM
alveolar cells type 1: 320 nCPM

Immune cell

basophil: 337 nTPM
neutrophil: 250 nTPM
total PBMC: 224 nTPM
myeloid DC: 204 nTPM
classical monocyte: 181 nTPM
non-classical monocyte: 168 nTPM

Brain region

medulla oblongata: 205 nTPM
thalamus: 200 nTPM
hypothalamus: 184 nTPM
pons: 158 nTPM
basal ganglia: 157 nTPM
white matter: 152 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.05
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

p53 binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTTG1IP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTTG1IP as an antibody target. Whether an autoantibody or antibody against PTTG1IP could matter depends on whether native PTTG1IP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTTG1IP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTTG1IP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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