Seroatlas · Human Serome Atlas

STX6

Syntaxin-6

Also known as: STX6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43752
Gene: STX6
Ensembl: ENSG00000135823
Chromosome: 1
Canonical length: 255 aa
Protein class: Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables syntaxin binding activity. Involved in regulation of protein localization; retrograde transport, endosome to Golgi; and vesicle fusion. Acts upstream of or within endocytic recycling. Located in several cellular components, including early endosome; perinuclear region of cytoplasm; and trans-Golgi network. Part of SNARE complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>O43752|STX6
     1  MSMEDPFFVV KGEVQKAVNT AQGLFQRWTE LLQDPSTATR EEIDWTTNEL RNNLRSIEWD
    61  LEDLDETISI VEANPRKFNL DATELSIRKA FITSTRQVVR DMKDQMSTSS VQALAERKNR
   121  QALLGDSGSQ NWSTGTTDKY GRLDRELQRA NSHFIEEQQA QQQLIVEQQD EQLELVSGSI
   181  GVLKNMSQRI GGELEEQAVM LEDFSHELES TQSRLDNVMK KLAKVSHMTS DRRQWCAIAI
   241  LFAVLLVVLI LFLVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STX6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 17 nTPM
esophagus: 17 nTPM
thymus: 16 nTPM
cerebellum: 15 nTPM
hippocampal formation: 14 nTPM
urinary bladder: 13 nTPM

Single-cell type

neutrophils: 125 nCPM
choroid plexus epithelial cells: 70 nCPM
microglia: 62 nCPM
macrophages: 58 nCPM
renal collecting duct intercalated cells: 55 nCPM
brain excitatory neurons: 52 nCPM

Immune cell

basophil: 2.4 nTPM
myeloid DC: 2.2 nTPM
eosinophil: 2 nTPM
classical monocyte: 1.6 nTPM
intermediate monocyte: 1.4 nTPM
naive CD4 T-cell: 1.4 nTPM

Brain region

white matter: 29 nTPM
cerebral cortex: 28 nTPM
cerebellum: 27 nTPM
hippocampal formation: 27 nTPM
basal ganglia: 25 nTPM
thalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.01
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STX6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STX6 as an antibody target. Whether an autoantibody or antibody against STX6 could matter depends on whether native STX6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STX6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STX6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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