Seroatlas · Human Serome Atlas

VPS45

Vacuolar protein sorting-associated protein 45

Also known as: h-vps45, H1, VPS45_HUMAN, VPS45A, VPS45B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRW7
Gene
VPS45
Ensembl
ENSG00000136631
Chromosome
1
Canonical length
570 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Microtubules

OverviewNCBI Gene

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q9NRW7|VPS45
     1  MNVVFAVKQY ISKMIEDSGP GMKVLLMDKE TTGIVSMVYT QSEILQKEVY LFERIDSQNR
    61  EIMKHLKAIC FLRPTKENVD YIIQELRRPK YTIYFIYFSN VISKSDVKSL AEADEQEVVA
   121  EVQEFYGDYI AVNPHLFSLN ILGCCQGRNW DPAQLSRTTQ GLTALLLSLK KCPMIRYQLS
   181  SEAAKRLAEC VKQVITKEYE LFEFRRTEVP PLLLILDRCD DAITPLLNQW TYQAMVHELL
   241  GINNNRIDLS RVPGISKDLR EVVLSAENDE FYANNMYLNF AEIGSNIKNL MEDFQKKKPK
   301  EQQKLESIAD MKAFVENYPQ FKKMSGTVSK HVTVVGELSR LVSERNLLEV SEVEQELACQ
   361  NDHSSALQNI KRLLQNPKVT EFDAARLVML YALHYERHSS NSLPGLMMDL RNKGVSEKYR
   421  KLVSAVVEYG GKRVRGSDLF SPKDAVAITK QFLKGLKGVE NVYTQHQPFL HETLDHLIKG
   481  RLKENLYPYL GPSTLRDRPQ DIIVFVIGGA TYEEALTVYN LNRTTPGVRI VLGGTTVHNT
   541  KSFLEEVLAS GLHSRSKESS QVTSRSASRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 34 nTPM
  • cerebellum: 33 nTPM
  • blood vessel: 28 nTPM
  • retina: 25 nTPM
  • parathyroid gland: 24 nTPM
  • choroid plexus: 23 nTPM

Single-cell type

  • late spermatids: 397 nCPM
  • early spermatids: 272 nCPM
  • cardiomyocytes: 245 nCPM
  • myonuclei: 207 nCPM
  • adrenal cortex cells: 140 nCPM
  • lactotrophs: 132 nCPM

Immune cell

  • intermediate monocyte: 26 nTPM
  • classical monocyte: 25 nTPM
  • myeloid DC: 24 nTPM
  • non-classical monocyte: 19 nTPM
  • total PBMC: 17 nTPM
  • basophil: 17 nTPM

Brain region

  • cerebellum: 27 nTPM
  • hypothalamus: 23 nTPM
  • basal ganglia: 22 nTPM
  • cerebral cortex: 22 nTPM
  • midbrain: 20 nTPM
  • amygdala: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VPS45.

Disease | AllUniProt

Conditions VPS45 is implicated in, by any mechanism.

  • Neutropenia, severe congenital 5, autosomal recessive (SCN5) MIM:615285

Disease | GeneticClinVar

16 pathogenic / likely-pathogenic of 697 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
1.63
DepMap mean gene effect
-0.33
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS45 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS45 as an antibody target. Whether an autoantibody or antibody against VPS45 could matter depends on whether native VPS45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VPS45. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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