Seroatlas · Human Serome Atlas

SYPL1

Synaptophysin-like protein 1

Also known as: SYPL, SYPL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16563
Gene: SYPL1
Ensembl: ENSG00000008282
Chromosome: 7
Canonical length: 259 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in chemical synaptic transmission. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q16563|SYPL1
     1  MAPNIYLVRQ RISRLGQRMS GFQINLNPLK EPLGFIKVLE WIASIFAFAT CGGFKGQTEI
    61  QVNCPPAVTE NKTVTATFGY PFRLNEASFQ PPPGVNICDV NWKDYVLIGD YSSSAQFYVT
   121  FAVFVFLYCI AALLLYVGYT SLYLDSRKLP MIDFVVTLVA TFLWLVSTSA WAKALTDIKI
   181  ATGHNIIDEL PPCKKKAVLC YFGSVTSMGS LNVSVIFGFL NMILWGGNAW FVYKETSLHS
   241  PSNTSAPHSQ GGIPPPTGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 190 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 190 nTPM
esophagus: 140 nTPM
skeletal muscle: 139 nTPM
salivary gland: 127 nTPM
kidney: 119 nTPM
parathyroid gland: 119 nTPM

Single-cell type

late primary spermatocytes: 939 nCPM
esophageal apical cells: 636 nCPM
early spermatids: 592 nCPM
esophageal suprabasal cells: 464 nCPM
esophageal basal cells: 345 nCPM
parietal cells: 336 nCPM

Immune cell

memory B-cell: 132 nTPM
naive B-cell: 129 nTPM
NK-cell: 72 nTPM
basophil: 69 nTPM
naive CD4 T-cell: 54 nTPM
eosinophil: 46 nTPM

Brain region

white matter: 135 nTPM
medulla oblongata: 113 nTPM
spinal cord: 79 nTPM
cerebellum: 77 nTPM
pons: 69 nTPM
midbrain: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0.05
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chemical synaptic transmission

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYPL1 as an antibody target. Whether an autoantibody or antibody against SYPL1 could matter depends on whether native SYPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYPL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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