Seroatlas · Human Serome Atlas

BCAP29

B-cell receptor-associated protein 29

Also known as: BAP29, BAP29_HUMAN, DKFZp686M2086

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHQ4
Gene: BCAP29
Ensembl: ENSG00000075790
Chromosome: 7
Canonical length: 241 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Involved in osteoblast differentiation. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>Q9UHQ4|BCAP29
     1  MTLQWAAVAT FLYAEIGLIL IFCLPFIPPQ RWQKIFSFNV WGKIATFWNK AFLTIIILLI
    61  VLFLDAVREV RKYSSVHTIE KSSTSRPDAY EHTQMKLFRS QRNLYISGFS LFFWLVLRRL
   121  VTLITQLAKE LSNKGVLKTQ AENTNKAAKK FMEENEKLKR ILKSHGKDEE CVLEAENKKL
   181  VEDQEKLKTE LRKTSDALSK AQNDVMEMKM QSERLSKEYD QLLKEHSELQ DRLERGNKKR
   241  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCAP29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 81 nTPM
testis: 66 nTPM
heart muscle: 58 nTPM
blood vessel: 49 nTPM
cervix: 47 nTPM
adipose tissue: 45 nTPM

Single-cell type

brain excitatory neurons: 84 nCPM
renal collecting duct intercalated cells: 84 nCPM
brain inhibitory neurons: 69 nCPM
oligodendrocyte progenitor cells: 65 nCPM
oligodendrocytes: 63 nCPM
bergmann glia: 61 nCPM

Immune cell

basophil: 50 nTPM
eosinophil: 26 nTPM
non-classical monocyte: 22 nTPM
intermediate monocyte: 14 nTPM
T-reg: 14 nTPM
memory B-cell: 13 nTPM

Brain region

cerebral cortex: 44 nTPM
basal ganglia: 42 nTPM
white matter: 38 nTPM
spinal cord: 35 nTPM
thalamus: 34 nTPM
hypothalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.26
gnomAD missense Z: -0.32
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCAP29 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCAP29 as an antibody target. Whether an autoantibody or antibody against BCAP29 could matter depends on whether native BCAP29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCAP29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCAP29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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