Seroatlas · Human Serome Atlas

TEX101

Testis-expressed protein 101

Also known as: CT131, MGC4766, SGRG, SPATA44, TES101RP, TX101_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY14
Gene: TEX101
Ensembl: ENSG00000131126
Chromosome: 19
Canonical length: 249 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to be involved in binding activity of sperm to zona pellucida; flagellated sperm motility; and regulation of flagellated sperm motility. Predicted to be located in acrosomal vesicle; extracellular region; and plasma membrane. Predicted to be active in plasma membrane raft. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q9BY14|TEX101
     1  MGTPRIQHLL ILLVLGASLL TSGLELYCQK GLSMTVEADP ANMFNWTTEE VETCDKGALC
    61  QETILIIKAG TETAILATKG CIPEGEEAIT IVQHSSPPGL IVTSYSNYCE DSFCNDKDSL
   121  SQFWEFSETT ASTVSTTLHC PTCVALGTCF SAPSLPCPNG TTRCYQGKLE ITGGGIESSV
   181  EVKGCTAMIG CRLMSGILAV GPMFVREACP HQLLTQPRKT ENGATCLPIP VWGLQLLLPL
   241  LLPSFIHFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEX101 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 111 nTPM

Expression across tissuesHPA

Tissue

testis: 111 nTPM
pancreas: 1.5 nTPM
skin: 1.4 nTPM
esophagus: 1.2 nTPM
tonsil: 1.2 nTPM
cervix: 1.1 nTPM

Single-cell type

early primary spermatocytes: 1,013 nCPM
differentiating spermatogonia: 74 nCPM
late primary spermatocytes: 57 nCPM
esophageal apical cells: 49 nCPM
undifferentiated spermatogonia: 35 nCPM
early spermatids: 10 nCPM

Immune cell

basophil: 56 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 45 nTPM
medulla oblongata: 8.7 nTPM
hippocampal formation: 5.2 nTPM
pons: 3.9 nTPM
spinal cord: 1.6 nTPM
white matter: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEX101 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEX101 as an antibody target. Whether an autoantibody or antibody against TEX101 could matter depends on whether native TEX101 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEX101 is annotated at the cell surface, where native TEX101 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TEX101 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...