Seroatlas · Human Serome Atlas

VTI1B

Vesicle transport through interaction with t-SNAREs homolog 1B

Also known as: VTI1B_HUMAN, VTI2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UEU0
Gene: VTI1B
Ensembl: ENSG00000100568
Chromosome: 14
Canonical length: 232 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables SNARE binding activity and chloride channel inhibitor activity. Involved in regulation of protein localization to plasma membrane. Located in several cellular components, including endosome membrane; lysosomal membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

232 residues, UniProt reviewed canonical sequence.

>Q9UEU0|VTI1B
     1  MASSAASSEH FEKLHEIFRG LHEDLQGVPE RLLGTAGTEE KKKLIRDFDE KQQEANETLA
    61  EMEEELRYAP LSFRNPMMSK LRNYRKDLAK LHREVRSTPL TATPGGRGDM KYGIYAVENE
   121  HMNRLQSQRA MLLQGTESLN RATQSIERSH RIATETDQIG SEIIEELGEQ RDQLERTKSR
   181  LVNTSENLSK SRKILRSMSR KVTTNKLLLS IIILLELAIL GGLVYYKFFR SH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VTI1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 87 nTPM

Expression across tissuesHPA

Tissue

amygdala: 87 nTPM
spinal cord: 78 nTPM
cerebral cortex: 73 nTPM
midbrain: 73 nTPM
basal ganglia: 70 nTPM
hippocampal formation: 67 nTPM

Single-cell type

late spermatids: 730 nCPM
esophageal apical cells: 419 nCPM
extravillous trophoblasts: 205 nCPM
megakaryocytes: 204 nCPM
esophageal suprabasal cells: 197 nCPM
late primary spermatocytes: 161 nCPM

Immune cell

eosinophil: 144 nTPM
basophil: 89 nTPM
intermediate monocyte: 81 nTPM
non-classical monocyte: 71 nTPM
classical monocyte: 62 nTPM
T-reg: 60 nTPM

Brain region

hypothalamus: 37 nTPM
cerebral cortex: 35 nTPM
midbrain: 33 nTPM
thalamus: 33 nTPM
white matter: 33 nTPM
pons: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.11
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.41
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VTI1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VTI1B as an antibody target. Whether an autoantibody or antibody against VTI1B could matter depends on whether native VTI1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VTI1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VTI1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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