Seroatlas · Human Serome Atlas

GMEB1

Glucocorticoid modulatory element-binding protein 1

Also known as: GMEB1_HUMAN, P96PIF, PIF96

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y692
Gene: GMEB1
Ensembl: ENSG00000162419
Chromosome: 1
Canonical length: 573 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

573 residues, UniProt reviewed canonical sequence.

>Q9Y692|GMEB1
     1  MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGLFIDGHF YNRIYEAGSE
    61  NNTAVVAVET HTIHKIEEGI DTGTIEANED MEIAYPITCG ESKAILLWKK FVCPGINVKC
   121  VKFNDQLISP KHFVHLAGKS TLKDWKRAIR LGGIMLRKMM DSGQIDFYQH DKVCSNTCRS
   181  TKFDLLISSA RAPVPGQQTS VVQTPTSADG SITQIAISEE SMEEAGLEWN SALTAAVTMA
   241  TEEGVKKDSE EISEDTLMFW KGIADVGLME EVVCNIQKEI EELLRGVQQR LIQAPFQVTD
   301  AAVLNNVAHT FGLMDTVKKV LDNRRNQVEQ GEEQFLYTLT DLERQLEEQK KQGQDHRLKS
   361  QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPPVQQP QFTVISPITI TPVGQSFSMG
   421  NIPVATLSQG SSPVTVHTLP SGPQLFRYAT VVSSAKSSSP DTVTIHPSSS LALLSSTAMQ
   481  DGSTLGNMTT MVSPVELVAM ESGLTSAIQA VESTSEDGQT IIEIDPAPDP EAEDTEGKAV
   541  ILETELRTEE KVVAEMEEHQ HQVHNVEIVV LED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GMEB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 13 nTPM
thymus: 9.9 nTPM
tonsil: 7.5 nTPM
lymph node: 6.3 nTPM
testis: 5.6 nTPM
appendix: 5.4 nTPM

Single-cell type

neutrophils: 79 nCPM
syncytiotrophoblasts: 71 nCPM
early primary spermatocytes: 65 nCPM
neutrophil progenitors: 60 nCPM
monocyte progenitors: 49 nCPM
esophageal apical cells: 47 nCPM

Immune cell

eosinophil: 9.9 nTPM
non-classical monocyte: 9 nTPM
basophil: 8 nTPM
memory CD8 T-cell: 7.9 nTPM
neutrophil: 7.6 nTPM
NK-cell: 7.5 nTPM

Brain region

cerebellum: 15 nTPM
choroid plexus: 9.5 nTPM
white matter: 9.1 nTPM
cerebral cortex: 8.7 nTPM
thalamus: 8.7 nTPM
medulla oblongata: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 2.37
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GMEB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GMEB1 as an antibody target. Whether an autoantibody or antibody against GMEB1 could matter depends on whether native GMEB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GMEB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GMEB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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