Seroatlas · Human Serome Atlas

RALGDS

Ral guanine nucleotide dissociation stimulator

Also known as: GNDS_HUMAN, RalGEF, RGDS, RGF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12967
Gene: RALGDS
Ensembl: ENSG00000160271
Chromosome: 9
Canonical length: 914 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

914 residues, UniProt reviewed canonical sequence.

>Q12967|RALGDS
     1  MVQRMWAEAA GPAGGAEPLF PGSRRSRSVW DAVRLEVGVP DSCPVVLHSF TQLDPDLPRP
    61  ESSTQEIGEE LINGVIYSIS LRKVQLHHGG NKGQRWLGYE NESALNLYET CKVRTVKAGT
   121  LEKLVEHLVP AFQGSDLSYV TIFLCTYRAF TTTQQVLDLL FKRYGRCDAL TASSRYGCIL
   181  PYSDEDGGPQ DQLKNAISSI LGTWLDQYSE DFCQPPDFPC LKQLVAYVQL NMPGSDLERR
   241  AHLLLAQLEH SEPIEAEPEA LSPVPALKPT PELELALTPA RAPSPVPAPA PEPEPAPTPA
   301  PGSELEVAPA PAPELQQAPE PAVGLESAPA PALELEPAPE QDPAPSQTLE LEPAPAPVPS
   361  LQPSWPSPVV AENGLSEEKP HLLVFPPDLV AEQFTLMDAE LFKKVVPYHC LGSIWSQRDK
   421  KGKEHLAPTI RATVTQFNSV ANCVITTCLG NRSTKAPDRA RVVEHWIEVA RECRILKNFS
   481  SLYAILSALQ SNSIHRLKKT WEDVSRDSFR IFQKLSEIFS DENNYSLSRE LLIKEGTSKF
   541  ATLEMNPKRA QKRPKETGII QGTVPYLGTF LTDLVMLDTA MKDYLYGRLI NFEKRRKEFE
   601  VIAQIKLLQS ACNNYSIAPD EQFGAWFRAV ERLSETESYN LSCELEPPSE SASNTLRTKK
   661  NTAIVKRWSD RQAPSTELST SGSSHSKSCD QLRCGPYLSS GDIADALSVH SAGSSSSDVE
   721  EINISFVPES PDGQEKKFWE SASQSSPETS GISSASSSTS SSSASTTPVA ATRTHKRSVS
   781  GLCNSSSALP LYNQQVGDCC IIRVSLDVDN GNMYKSILVT SQDKAPAVIR KAMDKHNLEE
   841  EEPEDYELLQ ILSDDRKLKI PENANVFYAM NSTANYDFVL KKRTFTKGVK VKHGASSTLP
   901  RMKQKGLKIA KGIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RALGDS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 102 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 102 nTPM
cerebellum: 82 nTPM
midbrain: 67 nTPM
hippocampal formation: 66 nTPM
pituitary gland: 65 nTPM
skin: 62 nTPM

Single-cell type

ocular epithelial cells: 179 nCPM
breast lactating cells: 142 nCPM
oligodendrocytes: 124 nCPM
somatotrophs: 120 nCPM
fallopian secretory cells: 112 nCPM
urothelial cells: 106 nCPM

Immune cell

gdT-cell: 24 nTPM
T-reg: 21 nTPM
memory CD8 T-cell: 18 nTPM
memory CD4 T-cell: 11 nTPM
MAIT T-cell: 9.7 nTPM
naive CD8 T-cell: 9.1 nTPM

Brain region

white matter: 199 nTPM
medulla oblongata: 152 nTPM
midbrain: 143 nTPM
basal ganglia: 142 nTPM
thalamus: 139 nTPM
pons: 129 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.89
gnomAD missense Z: 1.47
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Ras protein signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RALGDS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RALGDS as an antibody target. Whether an autoantibody or antibody against RALGDS could matter depends on whether native RALGDS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RALGDS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RALGDS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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