Seroatlas · Human Serome Atlas

TNFRSF14

Tumor necrosis factor receptor superfamily member 14

Also known as: ATAR, CD270, HVEA, HVEM, LIGHTR, TNR14_HUMAN, TR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92956
Gene
TNFRSF14
Ensembl
ENSG00000157873
Chromosome
1
Canonical length
283 aa
Protein class
Cancer-related genes, CD markers, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>Q92956|TNFRSF14
     1  MEPPGDWGPP PWRSTPKTDV LRLVLYLTFL GAPCYAPALP SCKEDEYPVG SECCPKCSPG
    61  YRVKEACGEL TGTVCEPCPP GTYIAHLNGL SKCLQCQMCD PAMGLRASRN CSRTENAVCG
   121  CSPGHFCIVQ DGDHCAACRA YATSSPGQRV QKGGTESQDT LCQNCPPGTF SPNGTLEECQ
   181  HQTKCSWLVT KAGAGTSSSH WVWWFLSGSL VIVIVCSTVG LIICVKRRKP RGDVVKVIVS
   241  VQRKRQEAEG EATVIEALQA PPDVTTVAVE ETIPSFTGRS PNH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
96 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 96 nTPM
  • adrenal gland: 71 nTPM
  • small intestine: 65 nTPM
  • liver: 61 nTPM
  • lung: 56 nTPM
  • kidney: 56 nTPM

Single-cell type

  • proximal tubule cells: 93 nCPM
  • papillary tip epithelial cells: 32 nCPM
  • renal collecting duct intercalated cells: 31 nCPM
  • renal collecting duct principal cells: 31 nCPM
  • podocytes: 28 nCPM
  • renal connecting tubule cells: 25 nCPM

Immune cell

  • neutrophil: 79 nTPM
  • intermediate monocyte: 68 nTPM
  • T-reg: 63 nTPM
  • naive CD4 T-cell: 52 nTPM
  • non-classical monocyte: 51 nTPM
  • naive B-cell: 50 nTPM

Brain region

  • choroid plexus: 4.8 nTPM
  • cerebral cortex: 2.7 nTPM
  • thalamus: 2.2 nTPM
  • hippocampal formation: 2.1 nTPM
  • medulla oblongata: 2 nTPM
  • white matter: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.81
gnomAD missense Z
0.61
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNFRSF14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFRSF14 as an antibody target. Whether an autoantibody or antibody against TNFRSF14 could matter depends on whether native TNFRSF14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFRSF14 is annotated at the cell surface, where native TNFRSF14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TNFRSF14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNFRSF14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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