Seroatlas · Human Serome Atlas

TRAF3IP1

TRAF3-interacting protein 1

Also known as: DKFZP434F124, FAP116, IFT54, MIP-T3, MIPT3, MIPT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDR0
Gene
TRAF3IP1
Ensembl
ENSG00000204104
Chromosome
2
Canonical length
691 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Nuclear bodies,Primary cilium transition zone

OverviewNCBI Gene

The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

691 residues, UniProt reviewed canonical sequence.

>Q8TDR0|TRAF3IP1
     1  MNAAVVRRTQ EALGKVIRRP PLTEKLLSKP PFRYLHDIIT EVIRMTGFMK GLYTDAEMKS
    61  DNVKDKDAKI SFLQKAIDVV VMVSGEPLLA KPARIVAGHE PERTNELLQI IGKCCLNKLS
   121  SDDAVRRVLA GEKGEVKGRA SLTSRSQELD NKNVREEESR VHKNTEDRGD AEIKERSTSR
   181  DRKQKEELKE DRKPREKDKD KEKAKENGGN RHREGERERA KARARPDNER QKDRGNRERD
   241  RDSERKKETE RKSEGGKEKE RLRDRDRERD RDKGKDRDRR RVKNGEHSWD LDREKNREHD
   301  KPEKKSASSG EMSKKLSDGT FKDSKAETET EISTRASKSL TTKTSKRRSK NSVEGRKEDN
   361  ISAKSLDSIV SGINNEPNQE TTTSEIGTKE ANINSTSISD DNSASLRCEN IQPNPTEKQK
   421  GDSTSDAEGD AGPAGQDKSE VPETPEIPNE LSSNIRRIPR PGSARPAPPR VKRQDSMEAL
   481  QMDRSGSGKT VSNVITESHN SDNEEDDQFV VEAAPQLSEM SEIEMVTAVE LEEEEKHGGL
   541  VKKILETKKD YEKLQQSPKP GEKERSLFES AWKKEKDIVS KEIEKLRTSI QTLCKSALPL
   601  GKIMDYIQED VDAMQNELQM WHSENRQHAE ALQQEQRITD CAVEPLKAEL AELEQLIKDQ
   661  QDKICAVKAN ILKNEEKIQK MVYSINLTSR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAF3IP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 18 nTPM
  • testis: 13 nTPM
  • epididymis: 12 nTPM
  • parathyroid gland: 11 nTPM
  • skeletal muscle: 11 nTPM
  • blood vessel: 11 nTPM

Single-cell type

  • respiratory ciliated cells: 475 nCPM
  • endometrial ciliated cells: 357 nCPM
  • fallopian tube ciliated cells: 344 nCPM
  • ependymal cells: 186 nCPM
  • pituicytes/fscs: 151 nCPM
  • choroid plexus epithelial cells: 129 nCPM

Immune cell

  • NK-cell: 2 nTPM
  • non-classical monocyte: 1.4 nTPM
  • MAIT T-cell: 0.6 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • gdT-cell: 0.3 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • midbrain: 19 nTPM
  • medulla oblongata: 18 nTPM
  • spinal cord: 17 nTPM
  • pons: 16 nTPM
  • hypothalamus: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAF3IP1.

Disease | AllUniProt

Conditions TRAF3IP1 is implicated in, by any mechanism.

Disease | GeneticClinVar

35 pathogenic / likely-pathogenic of 680 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Senior-Loken syndrome 9

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
0.33
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TRAF3-interacting protein 1
  • TRAF3-interacting protein 1, N-terminal
  • TRAF3-interacting protein 1, C-terminal domain
  • TRAF3-interacting protein 1, N-terminal domain superfamily
  • Microtubule-binding protein MIP-T3 CH-like domain
  • Microtubule-binding protein MIP-T3 C-terminal region

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRAF3IP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAF3IP1 as an antibody target. Whether an autoantibody or antibody against TRAF3IP1 could matter depends on whether native TRAF3IP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAF3IP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRAF3IP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAF3IP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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