TRAF/meprin, MATH domain

Definition

Intracellular TRAFs and extracellular meprins share a conserved region of about 180 residues, the the meprin and TRAF homology (MATH) domain which adopts a beta-sandwich structure. This is the MATH domain of TNF receptor-associated factors (TRAFs) and meprins. In TRAFS, it is essential for self-association and receptor interaction [[cite:PMID:10518213],[cite:PMID:19810754],[cite:PMID:18981220]]. Meprins are mammalian tissue-specific metalloendopeptidases involved developmental, normal and pathological processes.

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• TRAF1
• TRAF2
• TRAF3
• TRAF4
• TRAF5
• TRAF6