Seroatlas · Human Serome Atlas

OTUD7B

OTU domain-containing protein 7B

Also known as: CEZANNE, OTU7B_HUMAN, ZA20D1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6GQQ9
Gene: OTUD7B
Ensembl: ENSG00000264522
Chromosome: 1
Canonical length: 843 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Mitotic spindle

OverviewNCBI Gene

Enables K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of protein localization to nucleus; protein deubiquitination; and regulation of intracellular signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

843 residues, UniProt reviewed canonical sequence.

>Q6GQQ9|OTUD7B
     1  MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVNAALSD FEQLRQVHAG NLPPSFSEGS
    61  GGSRTPEKGF SDREPTRPPR PILQRQDDIV QEKRLSRGIS HASSSIVSLA RSHVSSNGGG
   121  GGSNEHPLEM PICAFQLPDL TVYNEDFRSF IERDLIEQSM LVALEQAGRL NWWVSVDPTS
   181  QRLLPLATTG DGNCLLHAAS LGMWGFHDRD LMLRKALYAL MEKGVEKEAL KRRWRWQQTQ
   241  QNKESGLVYT EDEWQKEWNE LIKLASSEPR MHLGTNGANC GGVESSEEPV YESLEEFHVF
   301  VLAHVLRRPI VVVADTMLRD SGGEAFAPIP FGGIYLPLEV PASQCHRSPL VLAYDQAHFS
   361  ALVSMEQKEN TKEQAVIPLT DSEYKLLPLH FAVDPGKGWE WGKDDSDNVR LASVILSLEV
   421  KLHLLHSYMN VKWIPLSSDA QAPLAQPESP TASAGDEPRS TPESGDSDKE SVGSSSTSNE
   481  GGRRKEKSKR DREKDKKRAD SVANKLGSFG KTLGSKLKKN MGGLMHSKGS KPGGVGTGLG
   541  GSSGTETLEK KKKNSLKSWK GGKEEAAGDG PVSEKPPAES VGNGGSKYSQ EVMQSLSILR
   601  TAMQGEGKFI FVGTLKMGHR HQYQEEMIQR YLSDAEERFL AEQKQKEAER KIMNGGIGGG
   661  PPPAKKPEPD AREEQPTGPP AESRAMAFST GYPGDFTIPR PSGGGVHCQE PRRQLAGGPC
   721  VGGLPPYATF PRQCPPGRPY PHQDSIPSLE PGSHSKDGLH RGALLPPPYR VADSYSNGYR
   781  EPPEPDGWAG GLRGLPPTQT KCKQPNCSFY GHPETNNFCS CCYREELRRR EREPDGELLV
   841  HRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTUD7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 19 nTPM
skeletal muscle: 17 nTPM
tongue: 15 nTPM
midbrain: 12 nTPM
testis: 12 nTPM
adipose tissue: 11 nTPM

Single-cell type

melanocytes: 252 nCPM
oligodendrocytes: 251 nCPM
schwann cells: 246 nCPM
myonuclei: 209 nCPM
pituicytes/fscs: 173 nCPM
cone photoreceptor cells: 164 nCPM

Immune cell

basophil: 2 nTPM
gdT-cell: 0.7 nTPM
MAIT T-cell: 0.5 nTPM
eosinophil: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
NK-cell: 0.4 nTPM

Brain region

medulla oblongata: 106 nTPM
white matter: 103 nTPM
basal ganglia: 98 nTPM
midbrain: 95 nTPM
thalamus: 83 nTPM
cerebellum: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.01
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OTUD7B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTUD7B as an antibody target. Whether an autoantibody or antibody against OTUD7B could matter depends on whether native OTUD7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTUD7B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OTUD7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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