Seroatlas · Human Serome Atlas

ATP1B1

Sodium/potassium-transporting ATPase subunit beta-1

Also known as: AT1B1_HUMAN, ATP1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P05026
Gene: ATP1B1
Ensembl: ENSG00000143153
Chromosome: 1
Canonical length: 303 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>P05026|ATP1B1
     1  MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF IGTIQVMLLT
    61  ISEFKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA YVLNIVRFLE KYKDSAQRDD
   121  MIFEDCGDVP SEPKERGDFN HERGERKVCR FKLEWLGNCS GLNDETYGYK EGKPCIIIKL
   181  NRVLGFKPKP PKNESLETYP VMKYNPNVLP VQCTGKRDED KDKVGNVEYF GLGNSPGFPL
   241  QYYPYYGKLL QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE
   301  VKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP1B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 1,377 nTPM

Expression across tissuesHPA

Tissue

kidney: 1,377 nTPM
parathyroid gland: 752 nTPM
stomach: 415 nTPM
choroid plexus: 414 nTPM
cerebral cortex: 413 nTPM
duodenum: 352 nTPM

Single-cell type

parietal cells: 3,522 nCPM
esophageal apical cells: 2,471 nCPM
salivary duct cells: 2,050 nCPM
distal convoluted tubule cells: 1,498 nCPM
renal connecting tubule cells: 1,483 nCPM
mucous neck cells: 1,403 nCPM

Immune cell

basophil: 15 nTPM
T-reg: 10 nTPM
myeloid DC: 9.2 nTPM
NK-cell: 6.4 nTPM
memory CD4 T-cell: 3.4 nTPM
intermediate monocyte: 3.1 nTPM

Brain region

pons: 1,169 nTPM
cerebral cortex: 932 nTPM
medulla oblongata: 855 nTPM
cerebellum: 800 nTPM
thalamus: 785 nTPM
white matter: 784 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 2
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP1B1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP1B1 as an antibody target. Whether an autoantibody or antibody against ATP1B1 could matter depends on whether native ATP1B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP1B1 is annotated at the cell surface, where native ATP1B1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATP1B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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