Seroatlas · Human Serome Atlas

TDP2

Tyrosyl-DNA phosphodiesterase 2

Also known as: TTRAP, TYDP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95551
Gene
TDP2
Ensembl
ENSG00000111802
Chromosome
6
Canonical length
362 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>O95551|TDP2
     1  MELGSCLEGG REAAEEEGEP EVKKRRLLCV EFASVASCDA AVAQCFLAEN DWEMERALNS
    61  YFEPPVEESA LERRPETISE PKTYVDLTNE ETTDSTTSKI SPSEDTQQEN GSMFSLITWN
   121  IDGLDLNNLS ERARGVCSYL ALYSPDVIFL QEVIPPYYSY LKKRSSNYEI ITGHEEGYFT
   181  AIMLKKSRVK LKSQEIIPFP STKMMRNLLC VHVNVSGNEL CLMTSHLEST RGHAAERMNQ
   241  LKMVLKKMQE APESATVIFA GDTNLRDREV TRCGGLPNNI VDVWEFLGKP KHCQYTWDTQ
   301  MNSNLGITAA CKLRFDRIFF RAAAEEGHII PRSLDLLGLE KLDCGRFPSD HWGLLCNLDI
   361  IL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
173 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 173 nTPM
  • colon: 133 nTPM
  • rectum: 120 nTPM
  • duodenum: 113 nTPM
  • kidney: 73 nTPM
  • prostate: 53 nTPM

Single-cell type

  • enterocytes: 657 nCPM
  • colonocytes: 527 nCPM
  • neutrophils: 337 nCPM
  • goblet cells: 222 nCPM
  • early spermatids: 197 nCPM
  • enteric transient amplifying cells: 156 nCPM

Immune cell

  • neutrophil: 230 nTPM
  • basophil: 76 nTPM
  • T-reg: 32 nTPM
  • MAIT T-cell: 31 nTPM
  • eosinophil: 29 nTPM
  • NK-cell: 29 nTPM

Brain region

  • thalamus: 34 nTPM
  • choroid plexus: 29 nTPM
  • cerebellum: 29 nTPM
  • midbrain: 27 nTPM
  • cerebral cortex: 27 nTPM
  • hypothalamus: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TDP2.

Disease | AllUniProt

Conditions TDP2 is implicated in, by any mechanism.

  • Spinocerebellar ataxia, autosomal recessive, 23 (SCAR23) MIM:616949

Disease | GeneticClinVar

14 pathogenic / likely-pathogenic of 112 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.11
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TDP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDP2 as an antibody target. Whether an autoantibody or antibody against TDP2 could matter depends on whether native TDP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TDP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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