Seroatlas · Human Serome Atlas

BIRC2

Baculoviral IAP repeat-containing protein 2

Also known as: API1, BIRC2_HUMAN, c-IAP1, cIAP1, hiap-2, MIHB, RNF48

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13490
Gene: BIRC2
Ensembl: ENSG00000110330
Chromosome: 11
Canonical length: 618 aa
Protein class: Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Canonical amino-acid sequenceUniProt

618 residues, UniProt reviewed canonical sequence.

>Q13490|BIRC2
     1  MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV
    61  PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS
   121  LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYSSLSPNP LNSRAVEDIS SSRTNPYSYA
   181  MSTEEARFLT YHMWPLTFLS PSELARAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMSEH
   241  RRHFPNCPFL ENSLETLRFS ISNLSMQTHA ARMRTFMYWP SSVPVQPEQL ASAGFYYVGR
   301  NDDVKCFCCD GGLRCWESGD DPWVEHAKWF PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL
   361  STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT
   421  GENYKTVNDI VSALLNAEDE KREEEKEKQA EEMASDDLSL IRKNRMALFQ QLTCVLPILD
   481  NLLKANVINK QEHDIIKQKT QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF
   541  VDKNMKYIPT EDVSGLSLEE QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR
   601  KCPICRGIIK GTVRTFLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BIRC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

thymus: 47 nTPM
liver: 41 nTPM
bone marrow: 34 nTPM
lymph node: 32 nTPM
pancreas: 32 nTPM
tongue: 31 nTPM

Single-cell type

neutrophils: 242 nCPM
hepatocytes: 218 nCPM
epididymal basal cells: 193 nCPM
epididymal principal cells: 155 nCPM
monocytes: 145 nCPM
endometrial luminal cells: 121 nCPM

Immune cell

eosinophil: 102 nTPM
basophil: 93 nTPM
neutrophil: 67 nTPM
non-classical monocyte: 44 nTPM
classical monocyte: 42 nTPM
intermediate monocyte: 40 nTPM

Brain region

white matter: 32 nTPM
choroid plexus: 28 nTPM
midbrain: 23 nTPM
medulla oblongata: 23 nTPM
hypothalamus: 23 nTPM
spinal cord: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BIRC2.

Disease | ImmuneIEDB

Conditions an epitope on BIRC2 was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.43
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BIRC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BIRC2 as an antibody target. Whether an autoantibody or antibody against BIRC2 could matter depends on whether native BIRC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BIRC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BIRC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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