Seroatlas · Human Serome Atlas

OTUD5

OTU domain-containing protein 5

Also known as: DKFZp761A052, DUBA, OTUD5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96G74
Gene: OTUD5
Ensembl: ENSG00000068308
Chromosome: X
Canonical length: 571 aa
Protein class: Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

571 residues, UniProt reviewed canonical sequence.

>Q96G74|OTUD5
     1  MTILPKKKPP PPDADPANEP PPPGPMPPAP RRGGGVGVGG GGTGVGGGDR DRDSGVVGAR
    61  PRASPPPQGP LPGPPGALHR WALAVPPGAV AGPRPQQASP PPCGGPGGPG GGPGDALGAA
   121  AAGVGAAGVV VGVGGAVGVG GCCSGPGHSK RRRQAPGVGA VGGGSPEREE VGAGYNSEDE
   181  YEAAAARIEA MDPATVEQQE HWFEKALRDK KGFIIKQMKE DGACLFRAVA DQVYGDQDMH
   241  EVVRKHCMDY LMKNADYFSN YVTEDFTTYI NRKRKNNCHG NHIEMQAMAE MYNRPVEVYQ
   301  YSTGTSAVEP INTFHGIHQN EDEPIRVSYH RNIHYNSVVN PNKATIGVGL GLPSFKPGFA
   361  EQSLMKNAIK TSEESWIEQQ MLEDKKRATD WEATNEAIEE QVARESYLQW LRDQEKQARQ
   421  VRGPSQPRKA SATCSSATAA ASSGLEEWTS RSPRQRSSAS SPEHPELHAE LGMKPPSPGT
   481  VLALAKPPSP CAPGTSSQFS AGADRATSPL VSLYPALECR ALIQQMSPSA FGLNDWDDDE
   541  ILASVLAVSQ QEYLDSMKKN KVHRDPPPDK S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTUD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

spleen: 57 nTPM
cerebral cortex: 54 nTPM
bone marrow: 54 nTPM
cerebellum: 53 nTPM
basal ganglia: 53 nTPM
amygdala: 48 nTPM

Single-cell type

neutrophils: 215 nCPM
platelets: 151 nCPM
plasma cells: 88 nCPM
esophageal apical cells: 81 nCPM
innate lymphoid cells: 80 nCPM
pdcs: 77 nCPM

Immune cell

NK-cell: 20 nTPM
memory B-cell: 8.6 nTPM
neutrophil: 8.3 nTPM
eosinophil: 7.5 nTPM
T-reg: 7.3 nTPM
naive CD8 T-cell: 7.1 nTPM

Brain region

pons: 84 nTPM
hypothalamus: 83 nTPM
cerebral cortex: 79 nTPM
basal ganglia: 78 nTPM
medulla oblongata: 78 nTPM
midbrain: 77 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about OTUD5.

Disease | AllUniProt

Conditions OTUD5 is implicated in, by any mechanism.

Multiple congenital anomalies-neurodevelopmental syndrome, X-linked (MCAND) MIM:301056

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 151 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Multiple congenital anomalies-neurodevelopmental syndrome, X-linked
Inborn genetic diseases
OTUD5-related disorder
Intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.99
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OTUD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TRAF3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTUD5 as an antibody target. Whether an autoantibody or antibody against OTUD5 could matter depends on whether native OTUD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTUD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OTUD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...