Seroatlas · Human Serome Atlas

OTUB2

Ubiquitin thioesterase OTUB2

Also known as: C14orf137, FLJ21916, MGC3102, OTUB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DC9
Gene: OTUB2
Ensembl: ENSG00000089723
Chromosome: 14
Canonical length: 234 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde); an active cysteine protease site is present in the OTU domain. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q96DC9|OTUB2
     1  MSETSFNLIS EKCDILSILR DHPENRIYRR KIEELSKRFT AIRKTKGDGN CFYRALGYSY
    61  LESLLGKSRE IFKFKERVLQ TPNDLLAAGF EEHKFRNFFN AFYSVVELVE KDGSVSSLLK
   121  VFNDQSASDH IVQFLRLLTS AFIRNRADFF RHFIDEEMDI KDFCTHEVEP MATECDHIQI
   181  TALSQALSIA LQVEYVDEMD TALNHHVFPE AATPSVYLLY KTSHYNILYA ADKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against OTUB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

testis: 13 nTPM
skin: 7.2 nTPM
esophagus: 3.7 nTPM
parathyroid gland: 1.8 nTPM
placenta: 1.7 nTPM
cervix: 1.5 nTPM

Single-cell type

late spermatids: 1,712 nCPM
early spermatids: 702 nCPM
syncytiotrophoblasts: 35 nCPM
late primary spermatocytes: 22 nCPM
esophageal apical cells: 16 nCPM
endometrial glandular cells: 4.6 nCPM

Immune cell

myeloid DC: 0.9 nTPM
intermediate monocyte: 0.8 nTPM
classical monocyte: 0.6 nTPM
non-classical monocyte: 0.6 nTPM
total PBMC: 0.2 nTPM
memory CD4 T-cell: 0.1 nTPM

Brain region

thalamus: 7.1 nTPM
cerebellum: 4.4 nTPM
cerebral cortex: 4.4 nTPM
amygdala: 4.3 nTPM
midbrain: 4.3 nTPM
basal ganglia: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of OTUB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads OTUB2 as an antibody target. Whether an autoantibody or antibody against OTUB2 could matter depends on whether native OTUB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

OTUB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label OTUB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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