TNFRSF9

Protein identityUniProt · HPA

UniProt accession

Q07011

Gene

TNFRSF9

Ensembl

ENSG00000049249

Chromosome

1

Canonical length

255 aa

Protein class

Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Nucleoli,Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>Q07011|TNFRSF9
     1  MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP NSFSSAGGQR
    61  TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS MCEQDCKQGQ ELTKKGCKDC
   121  CFGTFNDQKR GICRPWTNCS LDGKSVLVNG TKERDVVCGP SPADLSPGAS SVTPPAPARE
   181  PGHSPQIISF FLALTSTALL FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG
   241  CSCRFPEEEE GGCEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

9.2 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNFRSF9.

Disease | AllUniProt

Conditions TNFRSF9 is implicated in, by any mechanism.

• Immunodeficiency 109 with lymphoproliferation (IMD109) MIM:620282

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 207 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Lymphoma
• Squamous cell carcinoma of the head and neck
• TNFRSF9-related disorder

Disease | AutoantibodyPubMed

Conditions in which antibodies against TNFRSF9 are reported. Each links to that disease's full target list.

• Lupus Erythematosus, Systemic 3

ReferencesPubMed · IEDB

Publications for TNFRSF9 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.61

gnomAD pLI

0.32

gnomAD missense Z

0.36

DepMap mean gene effect

-0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• negative regulation of cell population proliferation
• regulation of cell population proliferation
• regulation of immature T cell proliferation in thymus

Molecular functions

• signaling receptor activity

Cellular components

• external side of plasma membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• TNFR/NGFR cysteine-rich region
• Growth factor receptor cysteine-rich domain superfamily
• TNFR/NGFR cysteine-rich region
• Tumour necrosis factor receptor 9
• Tumour necrosis factor receptor 9, N-terminal

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Membrane
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TNFRSF9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRAF1
• TRAF2
• TRAF3