Seroatlas · Human Serome Atlas

RIPK4

Receptor-interacting serine/threonine-protein kinase 4

Also known as: ANKK2, ANKRD3, DIK, PKK, RIP4, RIPK4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57078
Gene: RIPK4
Ensembl: ENSG00000183421
Chromosome: 21
Canonical length: 832 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

832 residues, UniProt reviewed canonical sequence.

>P57078|RIPK4
     1  MEGDGGTPWA LALLRTFDAG EFTGWEKVGS GGFGQVYKVR HVHWKTWLAI KCSPSLHVDD
    61  RERMELLEEA KKMEMAKFRY ILPVYGICRE PVGLVMEYME TGSLEKLLAS EPLPWDLRFR
   121  IIHETAVGMN FLHCMAPPLL HLDLKPANIL LDAHYHVKIS DFGLAKCNGL SHSHDLSMDG
   181  LFGTIAYLPP ERIREKSRLF DTKHDVYSFA IVIWGVLTQK KPFADEKNIL HIMVKVVKGH
   241  RPELPPVCRA RPRACSHLIR LMQRCWQGDP RVRPTFQGNG LNGELIRQVL AALLPVTGRW
   301  RSPGEGFRLE SEVIIRVTCP LSSPQEITSE TEDLCEKPDD EVKETAHDLD VKSPPEPRSE
   361  VVPARLKRAS APTFDNDYSL SELLSQLDSG VSQAVEGPEE LSRSSSESKL PSSGSGKRLS
   421  GVSSVDSAFS SRGSLSLSFE REPSTSDLGT TDVQKKKLVD AIVSGDTSKL MKILQPQDVD
   481  LALDSGASLL HLAVEAGQEE CAKWLLLNNA NPNLSNRRGS TPLHMAVERR VRGVVELLLA
   541  RKISVNAKDE DQWTALHFAA QNGDESSTRL LLEKNASVNE VDFEGRTPMH VACQHGQENI
   601  VRILLRRGVD VSLQGKDAWL PLHYAAWQGH LPIVKLLAKQ PGVSVNAQTL DGRTPLHLAA
   661  QRGHYRVARI LIDLCSDVNV CSLLAQTPLH VAAETGHTST ARLLLHRGAG KEAMTSDGYT
   721  ALHLAARNGH LATVKLLVEE KADVLARGPL NQTALHLAAA HGHSEVVEEL VSADVIDLFD
   781  EQGLSALHLA AQGRHAQTVE TLLRHGAHIN LQSLKFQGGH GPAATLLRRS KT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIPK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

esophagus: 70 nTPM
vagina: 22 nTPM
skin: 21 nTPM
liver: 18 nTPM
cervix: 17 nTPM
stomach: 15 nTPM

Single-cell type

endometrial luminal cells: 282 nCPM
endometrial glandular cells: 277 nCPM
esophageal apical cells: 267 nCPM
endometrial secretory cells: 124 nCPM
esophageal suprabasal cells: 117 nCPM
endometrial ciliated cells: 89 nCPM

Immune cell

neutrophil: 0.4 nTPM
naive CD4 T-cell: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 7.6 nTPM
midbrain: 1.2 nTPM
medulla oblongata: 0.6 nTPM
hippocampal formation: 0.3 nTPM
pons: 0.3 nTPM
amygdala: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RIPK4.

Disease | AllUniProt

Conditions RIPK4 is implicated in, by any mechanism.

Bartsocas-Papas syndrome (BPS) MIM:263650
CHAND syndrome (CHANDS) MIM:214350

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 328 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Bartsocas-Papas syndrome 1
Curly hair, ankyloblepharon, nail dysplasia syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 1.89
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIPK4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIPK4 as an antibody target. Whether an autoantibody or antibody against RIPK4 could matter depends on whether native RIPK4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIPK4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIPK4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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