Seroatlas · Human Serome Atlas

VAPA

Vesicle-associated membrane protein-associated protein A

Also known as: hVAP-33, VAP-A, VAPA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P0L0
Gene
VAPA
Ensembl
ENSG00000101558
Chromosome
18
Canonical length
249 aa
Protein class
Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location
Endoplasmic reticulum
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q9P0L0|VAPA
     1  MASASGAMAK HEQILVLDPP TDLKFKGPFT DVVTTNLKLR NPSDRKVCFK VKTTAPRRYC
    61  VRPNSGIIDP GSTVTVSVML QPFDYDPNEK SKHKFMVQTI FAPPNTSDME AVWKEAKPDE
   121  LMDSKLRCVF EMPNENDKLN DMEPSKAVPL NASKQDGPMP KPHSVSLNDT ETRKLMEECK
   181  RLQGEMMKLS EENRHLRDEG LRLRKVAHSD KPGSTSTASF RDNVTSPLPS LLVVIAAIFI
   241  GFFLGKFIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAPA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 92 nTPM
  • skeletal muscle: 64 nTPM
  • adrenal gland: 60 nTPM
  • esophagus: 43 nTPM
  • pancreas: 39 nTPM
  • blood vessel: 38 nTPM

Single-cell type

  • esophageal apical cells: 1,110 nCPM
  • neutrophils: 981 nCPM
  • basal keratinocytes: 567 nCPM
  • syncytiotrophoblasts: 552 nCPM
  • platelets: 496 nCPM
  • suprabasal keratinocytes: 493 nCPM

Immune cell

  • eosinophil: 252 nTPM
  • neutrophil: 227 nTPM
  • total PBMC: 184 nTPM
  • classical monocyte: 144 nTPM
  • basophil: 134 nTPM
  • intermediate monocyte: 128 nTPM

Brain region

  • pons: 79 nTPM
  • cerebellum: 71 nTPM
  • white matter: 68 nTPM
  • medulla oblongata: 68 nTPM
  • spinal cord: 65 nTPM
  • midbrain: 62 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about VAPA.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 50 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.35
gnomAD missense Z
0.95
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VAPA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAPA as an antibody target. Whether an autoantibody or antibody against VAPA could matter depends on whether native VAPA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAPA is annotated at the cell surface, where native VAPA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VAPA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VAPA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...