Seroatlas · Human Serome Atlas

RUSC1

AP-4 complex accessory subunit RUSC1

Also known as: NESCA, RUSC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BVN2
Gene: RUSC1
Ensembl: ENSG00000160753
Chromosome: 1
Canonical length: 902 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable actin binding activity. Involved in protein polyubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

902 residues, UniProt reviewed canonical sequence.

>Q9BVN2|RUSC1
     1  MLSPQRALLC NLNHIHLQHV SLGLHLSRRP ELQEGPLSTP PPPGDTGGKE SRGPCSGTLV
    61  DANSNSPAVP CRCCQEHGPG LENRQDPSQE EEGAASPSDP GCSSSLSSCS DLSPDESPVS
   121  VYLRDLPGDE DAHPQPSIIP LEQGSPLASA GPGTCSPDSF CCSPDSCSGA SSSPDPGLDS
   181  NCNALTTCQD VPSPGLEEED ERAEQDLPTS ELLEADDGKI DAGKTEPSWK INPIWKIDTE
   241  KTKAEWKTTE NNNTGWKNNG NVNSSWKSEP EKFDSGWKTN TRITDSGSKT DAGKIDGGWR
   301  SDVSEEPVPH RTITSFHELA QKRKRGPGLP LVPQAKKDRS DWLIVFSPDT ELPPSGSPGG
   361  SSAPPREVTT FKELRSRSRA PAPPVPPRDP PVGWALVPPR PPPPPVPPRR KKNRPGLQPI
   421  AEGQSEEGRA VSPAAGEEAP AAKEPGAQAG LEVRSSWSFA GVPGAQRLWM AEAQSGTGQL
   481  QEQKKGLLIA VSVSVDKIIS HFGAARNLVQ KAQLGDSRLS PDVGHLVLTT LCPALHALVA
   541  DGLKPFRKDL ITGQRRSSPW SVVEASVKPG SSTRSLGTLY SQVSRLAPLS SSRSRFHAFI
   601  LGLLNTKQLE LWFSSLQEDA GLLSLLYLPT GFFSLARGGC PSLSTELLLL LQPLSVLTFH
   661  LDLLFEHHHH LPLGPPQAPA PPGPPPALQQ TMQAMLHFGG RLAQSLRGTS KEAASDPSDS
   721  PNLPTPGSWW EQLTQASRVY ASGGTEGFPL SRWAPGRHGT AAEEGAQERP LPTDEMAPGR
   781  GLWLGRLFGV PGGPAENENG ALKSRRPSSW LPPTVSVLAL VKRGAPPEMP SPQELEASAP
   841  RMVQTHRAVR ALCDHTAARP DQLSFRRGEV LRVITTVDED WLRCGRDGME GLVPVGYTSL
   901  VL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RUSC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 88 nTPM
cerebral cortex: 60 nTPM
esophagus: 47 nTPM
hypothalamus: 43 nTPM
pituitary gland: 42 nTPM
blood vessel: 42 nTPM

Single-cell type

esophageal apical cells: 141 nCPM
extravillous trophoblasts: 97 nCPM
oocytes: 83 nCPM
esophageal suprabasal cells: 77 nCPM
colonocytes: 68 nCPM
esophageal basal cells: 56 nCPM

Immune cell

non-classical monocyte: 24 nTPM
intermediate monocyte: 9.4 nTPM
myeloid DC: 8.6 nTPM
classical monocyte: 7.9 nTPM
plasmacytoid DC: 7.9 nTPM
MAIT T-cell: 7.2 nTPM

Brain region

cerebral cortex: 109 nTPM
pons: 82 nTPM
basal ganglia: 72 nTPM
thalamus: 69 nTPM
hypothalamus: 66 nTPM
medulla oblongata: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.94
gnomAD missense Z: 1.45
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein polyubiquitination

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

SH3 domain
RUN domain
SH3-like domain superfamily
RUN domain superfamily
AP-4 complex accessory subunit RUSC1/2
RUN domain
Variant SH3 domain
AP-4 complex accessory subunit RUSC1, RUN domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RUSC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RUSC1 as an antibody target. Whether an autoantibody or antibody against RUSC1 could matter depends on whether native RUSC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RUSC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RUSC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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